PMID- 19039555
OWN - NLM
STAT- MEDLINE
DCOM- 20090114
LR  - 20161124
IS  - 0914-7187 (Print)
IS  - 0914-7187 (Linking)
VI  - 22
IP  - 9
DP  - 2008 Nov
TI  - 123I-BMIPP delayed scintigraphic imaging in patients with chronic heart failure.
PG  - 769-75
LID - 10.1007/s12149-008-0180-x [doi]
AB  - OBJECTIVE: The objective of the present study was to clarify the ability of 
      123I-beta-methyl-iodophenylpentadecanoic acid (123I-BMIPP) to evaluate the 
      heart-to-mediastinum (H/M) ratio and myocardial global washout rate (WR) in 
      patients with chronic heart failure (CHF). METHODS: The severity of CHF was 
      evaluated on the basis of the New York Heart Association (NYHA) classification. 
      Twenty patients with CHF (13 with idiopathic dilated cardiomyopathy and 7 with 
      ischemic cardiomyopathy) and 11 age-matched controls underwent myocardial 
      radionuclide imaging. Scintigraphic images were obtained from each participant at 
      the early (30 min following radio-isotope injection) and late (4 h) phases using 
      123I-BMIPP. The H/M ratio and WR were calculated from planar images. 
      Concentrations of plasma brain natriuretic peptide (BNP) were measured prior to 
      the scintigraphic study. RESULTS: The 123I-BMIPP uptake of early H/M and global 
      WR did not significantly differ among groups, but uptake of delayed H/M was 
      significantly lower in patients with NYHA class III than in controls (control 
      2.47 +/- 0.39; class III 1.78 +/- 0.28, P < 0.05). The uptake of delayed H/M and 
      global WR correlated with plasma log BNP in all participants (r = -0.38, P < 
      0.05; 0.43, P < 0.05, respectively). CONCLUSIONS: These data suggest that 
      123I-BMIPP uptake of delayed H/M enhances the image of CHF severity. The 
      myocardial WR of 123I-BMIPP also effectively depicted the severity of CHF.
FAU - Kida, Keisuke
AU  - Kida K
AD  - Division of Cardiology, Department of Internal Medicine, St. Marianna University 
      School of Medicine, 2-16-1 Sugao, Kawasaki, Kanagawa, 216-8511, Japan.
FAU - Akashi, Yoshihiro J
AU  - Akashi YJ
FAU - Yoneyama, Kihei
AU  - Yoneyama K
FAU - Shimokawa, Mitsuhiro
AU  - Shimokawa M
FAU - Musha, Haruki
AU  - Musha H
LA  - eng
PT  - Journal Article
DEP - 20081128
PL  - Japan
TA  - Ann Nucl Med
JT  - Annals of nuclear medicine
JID - 8913398
RN  - 0 (Fatty Acids)
RN  - 0 (Iodobenzenes)
RN  - 0 (Radiopharmaceuticals)
RN  - 0J7USQ749M (iodofiltic acid)
SB  - IM
MH  - Aged
MH  - Chronic Disease
MH  - *Fatty Acids
MH  - Female
MH  - Heart Failure/*diagnostic imaging
MH  - Humans
MH  - *Iodobenzenes
MH  - Male
MH  - Radionuclide Imaging
MH  - Radiopharmaceuticals
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Time Factors
EDAT- 2008/11/29 09:00
MHDA- 2009/01/15 09:00
CRDT- 2008/11/29 09:00
PHST- 2007/11/25 00:00 [received]
PHST- 2008/06/04 00:00 [accepted]
PHST- 2008/11/29 09:00 [pubmed]
PHST- 2009/01/15 09:00 [medline]
PHST- 2008/11/29 09:00 [entrez]
AID - 10.1007/s12149-008-0180-x [doi]
PST - ppublish
SO  - Ann Nucl Med. 2008 Nov;22(9):769-75. doi: 10.1007/s12149-008-0180-x. Epub 2008 
      Nov 28.