PMID- 19039756
OWN - NLM
STAT- MEDLINE
DCOM- 20090407
LR  - 20151119
IS  - 1898-018X (Electronic)
IS  - 1898-018X (Linking)
VI  - 15
IP  - 6
DP  - 2008
TI  - Natriuretic peptides in patients with atrial fibrillation.
PG  - 525-9
AB  - BACKGROUND: The aim of the study was to evaluate plasma natriuretic peptides 
      (NPs): atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) 
      concentrations in patients with paroxysmal, persistent and permanent atrial 
      fibrillation (AF). METHODS AND RESULTS: The study groups consisted of 23 patients 
      with paroxysmal AF, 42 patients with permanent AF and 77 patients with persistent 
      AF with normal left ventricular function. The mean ANP level was increased in AF 
      patients in the paroxysmal, persistent and permanent groups: 249 +/- 88.3 pg/mL; 
      258 +/- 89.7 pg/mL; 208 +/- 76.7 pg/mL, respectively, vs. 67 +/- 21.2 pg/mL in 
      the control subjects (p < 0.001). The mean BNP level was increased in AF patients 
      in the paroxysmal, persistent and permanent groups: 99.6 +/- 29.8 pg/mL; 82.3 +/- 
      33 pg/mL; 95.6 +/- 46.4 pg/mL, respectively, vs. 37.5 +/- 13 pg/mL in the control 
      group. Multivariate logistic regression analysis revealed a positive correlation 
      between ANP levels, maximal left atrial volume, heart rate and New York Heart 
      Association (NYHA) classification, in the persistent AF patients. A positive 
      correlation between plasma BNP levels and heart failure stage according to NYHA 
      classification in this group was found. Baseline ANP concentrations were 
      positively correlated with baseline BNP concentrations in AF patients. 
      CONCLUSIONS: Plasma NPs levels are increased in patients with paroxysmal, 
      persistent and permanent AF and normal left ventricle function, and positively 
      correlated with left atrial volume, heart rate and heart failure stage according 
      to NYHA classification. Neurohormonal assessment does not distinguish the type of 
      arrhythmia.
FAU - Wozakowska-Kaplon, Beata
AU  - Wozakowska-Kaplon B
AD  - Department of Cardiology Regional District Hospital, Institute for Medical 
      Education, University of Kielce, Poland. bw.kaplon@poczta.onet.pl
FAU - Opolski, Grzegorz
AU  - Opolski G
FAU - Herman, Zbigniew
AU  - Herman Z
FAU - Kosior, Dariusz
AU  - Kosior D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Poland
TA  - Cardiol J
JT  - Cardiology journal
JID - 101392712
RN  - 0 (Biomarkers)
RN  - 0 (Natriuretic Peptides)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Atrial Fibrillation/*blood/physiopathology
MH  - Atrial Natriuretic Factor/blood
MH  - Biomarkers/blood
MH  - Disease Progression
MH  - Electrocardiography, Ambulatory
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Natriuretic Peptides/*blood
MH  - Prognosis
MH  - Prospective Studies
MH  - Radioimmunoassay
MH  - Stroke Volume/physiology
EDAT- 2008/11/29 09:00
MHDA- 2009/04/08 09:00
CRDT- 2008/11/29 09:00
PHST- 2008/11/29 09:00 [pubmed]
PHST- 2009/04/08 09:00 [medline]
PHST- 2008/11/29 09:00 [entrez]
PST - ppublish
SO  - Cardiol J. 2008;15(6):525-9.