PMID- 19040061
OWN - NLM
STAT- MEDLINE
DCOM- 20090519
LR  - 20140226
IS  - 0578-1426 (Print)
IS  - 0578-1426 (Linking)
VI  - 47
IP  - 6
DP  - 2008 Jun
TI  - [WHO classification and cytogenetic analysis of 435 cases with myelodysplastic 
      syndrome].
PG  - 464-7
AB  - OBJECTIVE: To investigate the WHO classification and cytogenetic characteristics 
      of primary myelodysplastic syndrome (MDS) in adults of Shanghai area and then 
      compare them with those of western countries. METHODS: The consecutive samples of 
      435 patients with MDS in Sino-US Shanghai Leukemia Cooperative Group were 
      collected prospectively and diagnosed with WHO classification. Cytogenetic 
      analysis was performed using chromosome G-banding and fluorescence in situ 
      hybridization (FISH) techniques. RESULTS: The median onset age in the patients 
      was 58 (18-90) years. The proportion of cases with refractory cytopenia with 
      multilineage dysplasia (RCMD) was highest ,accounting for 69.6% (303/435). Other 
      subtypes were refractory anemia with excess blasts (RAEB) 24.1% (105/435), 
      refractory anemia (RA) 2.3% (10/435), myelodysplastic syndrome, unclassifiable 
      (MDS-U) 2.3% (10/435), refractory anemia with ringed sideroblasts (RAS) 1.2% 
      (5/435) and 5q-syndrome 0.5% (2/435) in turn. The proportions of RA, RAS and 
      5q-syndrome were higher in western countries and RCMD subtype was lower. Eleven 
      cases had failure of chromosome analysis. In the remaining 424 cases with success 
      the frequency of chromosome abnormality was 38.7%, with the highest in RAEB- I 
      (62.5%), and then RAEB-II (48.4%) and RCMD (34.5%) in turn. The sequence of 
      common chromosome abnormalities was + 8 (12.7% ), complex karyotype (9.0%), 
      chromosome translocation (7.8%), - 20q (6.6%), -7/-7q (5.2%), -5/-5q (4.2%) and- 
      Y(2.4%), while the sequential order in western countries -5/-5q, -7/-7q, +8, 11q 
      and 12p/12q. Chromosome prognosis was grouped according to International 
      Prognosis Scoring System (IPSS), 289 cases were in the group with good chromosome 
      prognosis (68.2%), 81 cases in group with medium prognosis (19.1%) and 54 cases 
      in group with poor prognosis (12.7%). Seventeen patients had normal chromosome 
      examination because of lower percentage of abnormal cells. However, the detection 
      sensitivity of abnormality with FISH may sometimes be high. CONCLUSIONS: The WHO 
      subtype and chromosome abnormality distributions of MDS in Shanghai were 
      different from those in western countries. The combination of FISH and 
      conventional chromosome examination could improve the detection sensitivity.
FAU - Wang, Xiao-Qin
AU  - Wang XQ
AD  - Hematology Department, Huashan Hospital, Fudan University, Shanghai 200040, 
      China. wangxiaoqin@shmu.edu.cn
CN  - Sino-US Shanghai Leukemia Cooperative Group
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Nei Ke Za Zhi
JT  - Zhonghua nei ke za zhi
JID - 16210490R
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - China
MH  - Chromosome Aberrations
MH  - *Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Myelodysplastic Syndromes/*classification/*genetics
MH  - World Health Organization
EDAT- 2008/12/02 09:00
MHDA- 2009/05/20 09:00
CRDT- 2008/12/02 09:00
PHST- 2008/12/02 09:00 [pubmed]
PHST- 2009/05/20 09:00 [medline]
PHST- 2008/12/02 09:00 [entrez]
PST - ppublish
SO  - Zhonghua Nei Ke Za Zhi. 2008 Jun;47(6):464-7.