PMID- 19040559
OWN - NLM
STAT- MEDLINE
DCOM- 20090402
LR  - 20191210
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 22
IP  - 6
DP  - 2008 Nov-Dec
TI  - CD30, a marker to detect the high-risk kidney transplant recipients.
PG  - 765-9
LID - 10.1111/j.1399-0012.2008.00876.x [doi]
AB  - BACKGROUND: Sensitization of potential renal transplant recipients may impact the 
      selection of donors and the outcome of transplant. Another element of the 
      potential kidney transplant recipient immune system that provides useful 
      information regarding the transplant outcome is the immunologic CD30 molecule. 
      METHODS AND RESULTS: This study shows a significant correlation between the 
      pre-transplant high level of soluble CD30 and increased incidence of 
      post-transplant infection. Only 7/34 (20.6%) of the patients who had a low level 
      of sCD30 (< 90 U/mL) developed infection as compared with the 25/58 (43.1%) of 
      the patients who had a high level (> 90 U/mL) of sCD30 (p < 0.04). Higher level 
      of sCD30 pre-transplant was also correlated with the increased level of serum 
      creatinine (p < 0.05) and pre-transplant malignancy (p < 0.04). A significant 
      higher level of sCD30 was also noted among females (74%), as compared with males 
      (50%) with p < 0.03. In addition, significant effect of 3-6 human leukocyte 
      antigen (HLA) mismatches on rejection was seen. CONCLUSIONS: These results show 
      that higher pre-transplant immunologic reactivity measured by sCD30 level was 
      associated with post-transplant outcome. The high level of sCD30 among females 
      may indicate an active immunologic status, perhaps because of previous 
      pregnancies.
FAU - Spiridon, Camelia
AU  - Spiridon C
AD  - Texas Medical Specialty, Inc., Dallas, TX 75230, USA.
FAU - Nikaein, Afzal
AU  - Nikaein A
FAU - Lerman, Mark
AU  - Lerman M
FAU - Hunt, Judson
AU  - Hunt J
FAU - Dickerman, Richard
AU  - Dickerman R
FAU - Mack, Michael
AU  - Mack M
LA  - eng
PT  - Journal Article
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (Biomarkers)
RN  - 0 (Ki-1 Antigen)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Biomarkers/*blood
MH  - Creatinine/analysis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Graft Rejection/blood/*diagnosis/immunology
MH  - Humans
MH  - Infections/blood/*diagnosis/microbiology
MH  - Ki-1 Antigen/*blood/immunology
MH  - Kidney Transplantation/*immunology
MH  - Male
MH  - Middle Aged
MH  - Postoperative Period
MH  - Prognosis
MH  - Risk Factors
MH  - Treatment Outcome
EDAT- 2008/12/02 09:00
MHDA- 2009/04/03 09:00
CRDT- 2008/12/02 09:00
PHST- 2008/12/02 09:00 [pubmed]
PHST- 2009/04/03 09:00 [medline]
PHST- 2008/12/02 09:00 [entrez]
AID - CTR876 [pii]
AID - 10.1111/j.1399-0012.2008.00876.x [doi]
PST - ppublish
SO  - Clin Transplant. 2008 Nov-Dec;22(6):765-9. doi: 10.1111/j.1399-0012.2008.00876.x.