PMID- 19041574
OWN - NLM
STAT- MEDLINE
DCOM- 20090227
LR  - 20161124
IS  - 1097-6795 (Electronic)
IS  - 0894-7317 (Linking)
VI  - 21
IP  - 12
DP  - 2008 Dec
TI  - Progression of left ventricular functional abnormalities in hypertensive patients 
      with heart failure: an ultrasonic two-dimensional speckle tracking study.
PG  - 1309-17
LID - 10.1016/j.echo.2008.10.006 [doi]
AB  - OBJECTIVE: Two-dimensional (2-D) strain imaging is a novel echocardiographic 
      technique for myocardial function evaluation. We sought to investigate left 
      ventricular (LV) systolic function in patients with heart failure caused by 
      hypertension using a 2-D strain approach and to validate this method against 
      Doppler strain measurements. METHODS: The study population comprised 81 patients 
      (66.4 +/- 7.4 years) with hypertension in New York Heart Association (NYHA) class 
      I to IV and 20 healthy controls. RESULTS: Decreased longitudinal strain was 
      demonstrated in the basal septal segment in NYHA I, in the basal and mid septal 
      and basal lateral segments in NYHA II, and in all segments in NYHA III and IV. 
      Radial and circumferential strain were reduced in patients with NYHA III and IV. 
      Independent predictors of strain were duration of HT, LV mass index, LV 
      end-diastolic volume index, and systolic blood pressure. The agreement between 
      2-D and Doppler strain remained within acceptable ranges (mean difference +/- 1 
      standard deviation: 0.61%-1.92% +/- 2.38%-2.92% for longitudinal strain in 
      particular segments and 4.98% +/- 5.26% for radial strain). CONCLUSION: In 
      hypertensive patients, (1) LV longitudinal systolic function progressively 
      deteriorates from NYHA I to IV and abnormalities commence in the basal septum, 
      (2) LV radial and circumferential systolic impairment appears in NYHA III and IV, 
      and (3) 2-D strain measurement provides a feasible tool for the quantitation of 
      LV systolic performance.
FAU - Kosmala, Wojciech
AU  - Kosmala W
AD  - Department of Cardiology, Wroclaw Medical University, Wroclaw, Poland. 
      kosmw@kard.am.wroc.pl
FAU - Plaksej, Rafal
AU  - Plaksej R
FAU - Strotmann, Joerg M
AU  - Strotmann JM
FAU - Weigel, Carla
AU  - Weigel C
FAU - Herrmann, Sebastian
AU  - Herrmann S
FAU - Niemann, Marcus
AU  - Niemann M
FAU - Mende, Hanna
AU  - Mende H
FAU - Stork, Stefan
AU  - Stork S
FAU - Angermann, Christiane E
AU  - Angermann CE
FAU - Wagner, Jens A
AU  - Wagner JA
FAU - Weidemann, Frank
AU  - Weidemann F
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Am Soc Echocardiogr
JT  - Journal of the American Society of Echocardiography : official publication of the 
      American Society of Echocardiography
JID - 8801388
SB  - IM
MH  - Aged
MH  - Echocardiography, Doppler/*methods
MH  - Elasticity Imaging Techniques/*methods
MH  - Female
MH  - Heart Failure/*complications/*diagnostic imaging
MH  - Humans
MH  - Hypertension/*complications/*diagnostic imaging
MH  - Male
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Ventricular Dysfunction, Left/*complications/*diagnostic imaging
EDAT- 2008/12/02 09:00
MHDA- 2009/02/28 09:00
CRDT- 2008/12/02 09:00
PHST- 2008/04/23 00:00 [received]
PHST- 2008/12/02 09:00 [pubmed]
PHST- 2009/02/28 09:00 [medline]
PHST- 2008/12/02 09:00 [entrez]
AID - S0894-7317(08)00613-5 [pii]
AID - 10.1016/j.echo.2008.10.006 [doi]
PST - ppublish
SO  - J Am Soc Echocardiogr. 2008 Dec;21(12):1309-17. doi: 10.1016/j.echo.2008.10.006.