PMID- 19042851
OWN - NLM
STAT- MEDLINE
DCOM- 20090217
LR  - 20191111
IS  - 1536-0539 (Electronic)
IS  - 1536-0288 (Linking)
VI  - 22
IP  - 3
DP  - 2008
TI  - Open-label, add-on study of tetrahydrocannabinol for chronic nonmalignant pain.
PG  - 213-7
AB  - Cannabinoids have been used for pain relief for centuries and recent studies have 
      investigated their analgesic and anti-inflammatory mechanisms, as well as 
      clinical efficacy, in treating chronic pain. We report an open-label study 
      addressed to evaluate the effect and adverse events of orally administered 
      Delta-9-tetrahydrocannabinol (Delta-9-THC) in 13 patients with chronic 
      nonmalignant pain (CNMP) unresponsive to conventional pharmacotherapy. The effect 
      of the treatment was assessed on an eight-item HRQoL questionnaire. Five out of 
      13 patients reported adequate response to the treatment while eight patients 
      reported inadequate or no response. Seven patients did not experience any adverse 
      events (AEs), six patients reported AEs, two of which discontinued the treatment. 
      We conclude that oral THC may be a valuable therapeutic option for selected 
      patients with CNMP that are unresponsive to previous treatments, though further 
      research is warranted to characterize those patients.
FAU - Haroutiunian, Simon
AU  - Haroutiunian S
AD  - Department of Anesthesiology, Hadassah-Hebrew University Medical Center, 
      Jerusalem, Israel.
FAU - Rosen, Gila
AU  - Rosen G
FAU - Shouval, Rivka
AU  - Shouval R
FAU - Davidson, Elyad
AU  - Davidson E
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - England
TA  - J Pain Palliat Care Pharmacother
JT  - Journal of pain & palliative care pharmacotherapy
JID - 101125608
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 7J8897W37S (Dronabinol)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Analgesics, Non-Narcotic/administration & dosage/adverse effects/*therapeutic use
MH  - Chronic Disease
MH  - Dronabinol/administration & dosage/adverse effects/*therapeutic use
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain, Intractable/*drug therapy
MH  - Pilot Projects
MH  - Psychometrics
MH  - Quality of Life
MH  - Surveys and Questionnaires
EDAT- 2008/12/02 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/12/02 09:00
PHST- 2008/12/02 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PHST- 2008/12/02 09:00 [entrez]
AID - 10.1080/15360280802251215 [doi]
PST - ppublish
SO  - J Pain Palliat Care Pharmacother. 2008;22(3):213-7. doi: 
      10.1080/15360280802251215.