PMID- 19043310
OWN - NLM
STAT- MEDLINE
DCOM- 20090116
LR  - 20240109
IS  - 1229-845X (Print)
IS  - 1976-555X (Electronic)
IS  - 1229-845X (Linking)
VI  - 9
IP  - 4
DP  - 2008 Dec
TI  - Radioprotective effects of fucoidan on bone marrow cells: improvement of the cell 
      survival and immunoreactivity.
PG  - 359-65
AB  - Fucoidan is a sulfated polysaccharide purified from brown algae including Fucus 
      vesiculosus and has a variety of biological effects including mobilization of 
      hematopoietic progenitor cells. Recently, we demonstrated that fucoidan 
      stimulates the antigen-presenting functions of dendritic cells. In this study, we 
      investigated the radioprotective effects of fucoidan on bone marrow cells (BMCs), 
      which are the main cellular reservoir for the hematopoietic and immune system. To 
      evaluate the effects of fucoidan, we assayed cell viability and immune responses. 
      In a viability assay, fucoidan significantly increased the viability of BMCs. 
      Based on the results of flow cytometric analysis, the increased viability of 
      fucoidan-treated BMCs was attributed to the inhibition of radiation-induced 
      apoptosis. Furthermore, fucoidan altered the production of immune-related 
      cytokines from BMCs and increased the capability of BMCs to induce proliferation 
      of allogeneic splenocytes. Taken together, our study demonstrated that fucoidan 
      has radioprotective effects on BMCs with respect to cell viability and 
      immunoreactivity. These results may provide valuable information, useful in the 
      field of radiotherapy.
FAU - Byon, Yun Young
AU  - Byon YY
AD  - College of Veterinary Medicine, Cheju National University, Jeju 690-756, Korea.
FAU - Kim, Mi Hyoung
AU  - Kim MH
FAU - Yoo, Eun Sook
AU  - Yoo ES
FAU - Hwang, Kyu Kye
AU  - Hwang KK
FAU - Jee, Youngheun
AU  - Jee Y
FAU - Shin, Taekyun
AU  - Shin T
FAU - Joo, Hong Gu
AU  - Joo HG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Korea (South)
TA  - J Vet Sci
JT  - Journal of veterinary science
JID - 100964185
RN  - 0 (Polysaccharides)
RN  - 0 (Radiation-Protective Agents)
RN  - 9072-19-9 (fucoidan)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/*drug effects/*radiation effects
MH  - Cell Death/drug effects/radiation effects
MH  - Cell Proliferation
MH  - Cell Survival/drug effects
MH  - Cells, Cultured
MH  - Female
MH  - Gamma Rays/*adverse effects
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Polysaccharides/*pharmacology
MH  - Radiation-Protective Agents/*pharmacology
MH  - Spleen/cytology
PMC - PMC2811776
EDAT- 2008/12/02 09:00
MHDA- 2009/01/17 09:00
PMCR- 2008/12/01
CRDT- 2008/12/02 09:00
PHST- 2008/12/02 09:00 [pubmed]
PHST- 2009/01/17 09:00 [medline]
PHST- 2008/12/02 09:00 [entrez]
PHST- 2008/12/01 00:00 [pmc-release]
AID - 200812359 [pii]
AID - 10.4142/jvs.2008.9.4.359 [doi]
PST - ppublish
SO  - J Vet Sci. 2008 Dec;9(4):359-65. doi: 10.4142/jvs.2008.9.4.359.