PMID- 19043513
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20110517
LR  - 20211020
IS  - 1176-6328 (Print)
IS  - 1178-2021 (Electronic)
IS  - 1176-6328 (Linking)
VI  - 4
IP  - 4
DP  - 2008 Aug
TI  - Beneficial effect of pramipexole for motor function and depression in Parkinson's 
      disease.
PG  - 707-10
AB  - We examined whether pramipexole (PPX) can influence depressive scale in normal 
      and mild depressive parkinsonian patients. In an open study of PPX as an add-on 
      to L-dopa therapy or single administration, 36 nondemented outpatients with 
      Parkinson's disease (PD) were entered first. All were in the stage II or III of 
      Hoehn and Yahr scale (H&Y). PPX were started at 0.125 mg/day and daily doses were 
      increased to 1.5 mg/day. At 3 months after PPX treatment, patients were 
      re-evaluated. Hamilton Depression Rating Scale (HAM-D), Unified Parkinson's 
      Disease Rating Scale III, H&Y stage, and freezing of gait questionnaire were 
      compared in patients before and after PPX treatment. These scores were 
      significantly improved after PPX administration. There were no correlations 
      between HAM-D and those motor functions. We suggest that PPX treatment has 
      antidepressant effects in depressive PD patients and also ameliorates HAM-D score 
      in nondepressive PD patients in addition to motor function.
FAU - Kano, Osamu
AU  - Kano O
AD  - Department of Neurology, Methodist Neurological Institute, 6565 Fannin St F772 
      Houston, TX, USA. osamukano@aol.com
FAU - Ikeda, Ken
AU  - Ikeda K
FAU - Kiyozuka, Tetsuhito
AU  - Kiyozuka T
FAU - Iwamoto, Konosuke
AU  - Iwamoto K
FAU - Ito, Hirono
AU  - Ito H
FAU - Kawase, Yuji
AU  - Kawase Y
FAU - Sato, Ryuta
AU  - Sato R
FAU - Fujioka, Toshiki
AU  - Fujioka T
FAU - Araki, Yo
AU  - Araki Y
FAU - Baba, Shigeji
AU  - Baba S
FAU - Iwasaki, Yasuo
AU  - Iwasaki Y
LA  - eng
PT  - Journal Article
PL  - New Zealand
TA  - Neuropsychiatr Dis Treat
JT  - Neuropsychiatric disease and treatment
JID - 101240304
PMC - PMC2536536
OTO - NOTNLM
OT  - Parkinson disease
OT  - antidepressant effect
OT  - depression
OT  - motor function
OT  - pramipexole
EDAT- 2008/12/02 09:00
MHDA- 2008/12/02 09:01
PMCR- 2008/12/01
CRDT- 2008/12/02 09:00
PHST- 2008/12/02 09:00 [pubmed]
PHST- 2008/12/02 09:01 [medline]
PHST- 2008/12/02 09:00 [entrez]
PHST- 2008/12/01 00:00 [pmc-release]
PST - ppublish
SO  - Neuropsychiatr Dis Treat. 2008 Aug;4(4):707-10.