PMID- 19043830
OWN - NLM
STAT- MEDLINE
DCOM- 20090105
LR  - 20191111
IS  - 0935-8943 (Print)
IS  - 0935-8943 (Linking)
VI  - 87
IP  - 11
DP  - 2008 Nov
TI  - [Biomorphology of the Bacterial Invasion in Chronic pharyngotonsillitis ].
PG  - 776-82
AB  - BACKGROUND: The study investigates whether relapses of chronicpharyngotonsillitis 
      result from new infections caused by theoro-pharyngeal microbial flora or are 
      reactivations of persistent bacterial infections of the tonsils. METHODS: 90 
      patients, who were surgically treated for chronicpharyngotonsillitis (age 13 
      months to 38 years, at least 5 episodes of disease and antibiotic treatment in 
      the past) were included. The surgery was performed in the antibiotic- and 
      symptom-free period (at least 6 weeks after the last exacerbation). Sections of 
      tonsillar tissue were investigated for invasive bacteria using fluorescence in 
      situ hybridization (FISH) with group and species-specific 15/23S RNA based 
      probes. RESULTS: Abundant foci of invasive bacteria were found in 86% of the 
      resected tonsils, despite previous treatment with antibiotica and absent symptoms 
      of ongoing infection. The diffuse infiltration of the tonsils was most 
      predominant in the youger children. Local invasive processes such as abscesses, 
      fissures filled with pus and superficial infiltration of the tonsillar epithelium 
      were more typical for adults. All of the foci were polymicrobial and contained up 
      to 10 different species or groups of bacteria. The local concentrations of 
      invasive bacteria were up to 1012 bacteria/ml. CONCLUSIONS: The chronic 
      pharyngotonsillitis is the result of persistent invasive bacterial infections. 
      The polymicrobial nature of the infectious foci enables them to resist the 
      antibiotic treatment and to exacerbate afterwards. The surgical treatment is 
      unavoidable as long as antibiotic treatment fails to clear the infection.
FAU - Swidsinski, A
AU  - Swidsinski A
AD  - Charite, Humboldt Universitat, CCM, Klinik fur Gastroenterologie, 
      Molekular-genetisches Labor fur mukosale Pathogene, Berlin, Germany.
FAU - Dorffel, Y
AU  - Dorffel Y
FAU - Loening-Baucke, V
AU  - Loening-Baucke V
FAU - Swidsinski, S
AU  - Swidsinski S
FAU - Schmidt, A G
AU  - Schmidt AG
FAU - Scherer, H
AU  - Scherer H
FAU - Bessler, C
AU  - Bessler C
FAU - Goktas, O
AU  - Goktas O
LA  - ger
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
TT  - Biomorphologie der Infektionsherde in rezidivierenden Mandelentzundungen.
PL  - Germany
TA  - Laryngorhinootologie
JT  - Laryngo- rhino- otologie
JID - 8912371
RN  - 0 (Anti-Bacterial Agents)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Analysis of Variance
MH  - Anti-Bacterial Agents/pharmacology/therapeutic use
MH  - Bacteria/drug effects/*isolation & purification
MH  - *Bacterial Infections/diagnosis/drug therapy
MH  - Biofilms
MH  - Child
MH  - Child, Preschool
MH  - Chronic Disease
MH  - Drug Resistance, Bacterial
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Palatine Tonsil/*microbiology/pathology
MH  - Pharyngitis/*microbiology/surgery
MH  - Recurrence
MH  - Tonsillitis/drug therapy/*microbiology/surgery
EDAT- 2008/12/02 09:00
MHDA- 2009/01/06 09:00
CRDT- 2008/12/02 09:00
PHST- 2008/12/02 09:00 [pubmed]
PHST- 2009/01/06 09:00 [medline]
PHST- 2008/12/02 09:00 [entrez]
AID - 10.1055/s-2008-1077300 [doi]
PST - ppublish
SO  - Laryngorhinootologie. 2008 Nov;87(11):776-82. doi: 10.1055/s-2008-1077300.