PMID- 19043967
OWN - NLM
STAT- MEDLINE
DCOM- 20090225
LR  - 20131121
IS  - 0016-3813 (Print)
IS  - 0016-3813 (Linking)
VI  - 144
IP  - 5
DP  - 2008 Sep-Oct
TI  - [Pharmacogenomics of methrotexate: a strategy for a customized therapeutic scheme 
      for patients with rheumatoid arthritis].
PG  - 449-51
AB  - Rheumatoid arthritis (RA) is a common rheumatic disease in Mexico. Methotrexate 
      (MTX) is a drug frequently used in the treatment of this disease. However, 
      treatment discontinuation due to side effects is also common. Inter-individual 
      differences in effectiveness and occurrence of side effects in RA patients 
      treated with MTX (RA-MTX) have been reported. Several studies analyzed the 
      presence of MTHFR C677T and A1298C polymorphisms in RA-MTX patients associated 
      with effectiveness, side effects and toxicity. Given the high frequency of the 
      MTHFR C677T polymorphism in Mexico, it is of utmost interest to determine the 
      allelic and genotypic frequency of these polymorphisms in patients with RA-MTX. 
      The use of molecular techniques, feasible in our country, such as PCR/RFLP 
      (Polymerase Chain Reaction-Restriction Fragment Length Polymorphism) can allow us 
      to identify these MTHFR genotypes among RA-MTX patients in order to target 
      patients at risk of developing drug toxicity, side effects or better MTX 
      efficacy. The ultimate goal is to develop individualized treatment, as promised 
      by the field of pharmacogenomics.
FAU - Mena-Ramirez, Juan Pablo
AU  - Mena-Ramirez JP
AD  - CUCS Universidad de Guadalajara y Division de Genetica, Centro de Investigacion 
      Biomedica de Occidente, Guadalajara, Jalisco, Mexico. pabismen2000@yahoo.com.mx
FAU - Salazar-Paramo, Mario
AU  - Salazar-Paramo M
FAU - Davalos-Rodriguez, Ingrid P
AU  - Davalos-Rodriguez IP
LA  - spa
PT  - English Abstract
PT  - Journal Article
TT  - Farmacogenomica del metotrexate: estrategia para una terapeutica mas 
      individualizada en pacientes con artritis reumatoide.
PL  - Mexico
TA  - Gac Med Mex
JT  - Gaceta medica de Mexico
JID - 0010333
RN  - 0 (Antirheumatic Agents)
RN  - YL5FZ2Y5U1 (Methotrexate)
SB  - IM
MH  - Antirheumatic Agents/*pharmacology/*therapeutic use
MH  - Arthritis, Rheumatoid/*drug therapy/*genetics
MH  - Humans
MH  - Methotrexate/*pharmacology/*therapeutic use
MH  - Pharmacogenetics
EDAT- 2008/12/03 09:00
MHDA- 2009/02/26 09:00
CRDT- 2008/12/03 09:00
PHST- 2008/12/03 09:00 [pubmed]
PHST- 2009/02/26 09:00 [medline]
PHST- 2008/12/03 09:00 [entrez]
PST - ppublish
SO  - Gac Med Mex. 2008 Sep-Oct;144(5):449-51.