PMID- 19047007
OWN - NLM
STAT- MEDLINE
DCOM- 20090327
LR  - 20121115
IS  - 1096-0295 (Electronic)
IS  - 0273-2300 (Linking)
VI  - 53
IP  - 1
DP  - 2009 Feb
TI  - Developmental toxic potential of 1,3-dichloro-2-propanol in Sprague-Dawley rats.
PG  - 63-9
LID - 10.1016/j.yrtph.2008.11.001 [doi]
AB  - This study investigated the potential adverse effects of 1,3-dichloro-2-propanol 
      (1,3-DCP) on pregnant dams and the embryo-fetal development after maternal 
      exposure on gestational days (GD) 6 through 19 in Sprague-Dawley rats. The test 
      chemical was administered to pregnant rats by gavage at dose levels of 0, 10, 30, 
      and 90mg/kg per day (n=10 for each group). All dams underwent Caesarean sections 
      on GD 20, and their fetuses were examined for morphological abnormalities. 
      Maternal toxicity was noted at 90mg/kg/day. Manifestations of toxicity included 
      clinical signs of illness, lower body weight gain, decreased food intake, and 
      increases in the weight of the adrenal glands and the liver. Developmental toxic 
      effects including decreases in fetal body weight and increases in visceral and 
      skeletal variations also occurred at the highest dose. At 30mg/kg, only a minimal 
      maternal toxicity, including a decrease in maternal food intake and an increase 
      in the liver weight, was observed. No adverse maternal or developmental effects 
      were observed at 10mg/kg/day. These results revealed that a 14-day repeated oral 
      dose of 1,3-DCP was minimally embryotoxic but not teratogenic at a maternal toxic 
      dose (90mg/kg/day), and was not embryotoxic at a minimally maternal toxic dose 
      (30mg/kg/day) in rats. Because the developmental toxicity of 1,3-DCP was observed 
      only in the presence of maternal toxicity, it is concluded that the developmental 
      findings observed in the present study are secondary effects to maternal 
      toxicity. Under these experimental conditions, the no-observed-adverse-effect 
      level of 1,3-DCP is considered to be 10mg/kg/day for dams and 30mg/kg/day for 
      embryo-fetal development.
FAU - Lee, J C
AU  - Lee JC
AD  - Animal Medical Center, College of Veterinary Medicine, Chonnam National 
      University, Gwangju 500-757, South Korea.
FAU - Shin, I S
AU  - Shin IS
FAU - Ahn, T H
AU  - Ahn TH
FAU - Kim, K H
AU  - Kim KH
FAU - Moon, C
AU  - Moon C
FAU - Kim, S H
AU  - Kim SH
FAU - Shin, D H
AU  - Shin DH
FAU - Park, S C
AU  - Park SC
FAU - Kim, Y B
AU  - Kim YB
FAU - Kim, J C
AU  - Kim JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081120
PL  - Netherlands
TA  - Regul Toxicol Pharmacol
JT  - Regulatory toxicology and pharmacology : RTP
JID - 8214983
RN  - 0 (Mutagens)
RN  - 0F4P2VQC07 (1,3-dichloro-2-propanol)
RN  - 96-24-2 (alpha-Chlorohydrin)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Eating/drug effects
MH  - Female
MH  - Fetal Development/*drug effects
MH  - Fetal Weight/drug effects
MH  - Male
MH  - *Maternal Exposure
MH  - Mutagens/administration & dosage/*toxicity
MH  - No-Observed-Adverse-Effect Level
MH  - Organ Size/drug effects
MH  - Pregnancy
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Weight Gain/drug effects
MH  - alpha-Chlorohydrin/administration & dosage/*analogs & derivatives/toxicity
EDAT- 2008/12/03 09:00
MHDA- 2009/03/28 09:00
CRDT- 2008/12/03 09:00
PHST- 2008/09/10 00:00 [received]
PHST- 2008/11/10 00:00 [revised]
PHST- 2008/11/12 00:00 [accepted]
PHST- 2008/12/03 09:00 [pubmed]
PHST- 2009/03/28 09:00 [medline]
PHST- 2008/12/03 09:00 [entrez]
AID - S0273-2300(08)00250-X [pii]
AID - 10.1016/j.yrtph.2008.11.001 [doi]
PST - ppublish
SO  - Regul Toxicol Pharmacol. 2009 Feb;53(1):63-9. doi: 10.1016/j.yrtph.2008.11.001. 
      Epub 2008 Nov 20.