PMID- 1904794
OWN - NLM
STAT- MEDLINE
DCOM- 19910723
LR  - 20190619
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 68
IP  - 1
DP  - 1991 Jul 1
TI  - High-energy proton beam radiation therapy for gynecologic malignancies. Potential 
      of proton beam as an alternative to brachytherapy.
PG  - 79-83
AB  - Fifteen patients with advanced gynecologic malignancies were treated with 
      high-energy proton beam radiation therapy (RT) at the Particle Radiation Medical 
      Science Center (PARMS), Tsukuba University, Japan, from 1983 to 1987. The 
      potential of proton beam RT as an alternative to conventional brachytherapy was 
      evaluated. Except for one local recurrence, 14 of 15 patients were locoregionally 
      controlled for 15 to 57 months. Two-year local control rate and 2-year survival 
      rate were 92.3% and 93.3%, respectively. Two cases of transient, 
      radiation-induced proctitis (neither of which required surgical treatment) were 
      the only complications despite a target dose that exceeded 8000 cGy in most 
      cases. The results suggest that sharply localized, high-dose proton beam RT can 
      produce an antitumor effect equivalent to that of conventional brachytherapy.
FAU - Arimoto, T
AU  - Arimoto T
AD  - Department of Radiology, Hokkaido University, School of Medicine, Sapporo, Japan.
FAU - Kitagawa, T
AU  - Kitagawa T
FAU - Tsujii, H
AU  - Tsujii H
FAU - Ohhara, K
AU  - Ohhara K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - IM
MH  - Aged
MH  - Brachytherapy
MH  - Female
MH  - Humans
MH  - Lymphatic Irradiation
MH  - Middle Aged
MH  - Neoplasm Recurrence, Local
MH  - Radiotherapy Dosage
MH  - *Radiotherapy, High-Energy/adverse effects
MH  - Survival Rate
MH  - Uterine Cervical Neoplasms/mortality/*radiotherapy
MH  - Uterine Cervicitis/etiology
MH  - Vaginal Neoplasms/mortality/*radiotherapy
MH  - Vaginitis/etiology
EDAT- 1991/07/01 00:00
MHDA- 1991/07/01 00:01
CRDT- 1991/07/01 00:00
PHST- 1991/07/01 00:00 [pubmed]
PHST- 1991/07/01 00:01 [medline]
PHST- 1991/07/01 00:00 [entrez]
AID - 10.1002/1097-0142(19910701)68:1<79::aid-cncr2820680116>3.0.co;2-9 [doi]
PST - ppublish
SO  - Cancer. 1991 Jul 1;68(1):79-83. doi: 
      10.1002/1097-0142(19910701)68:1<79::aid-cncr2820680116>3.0.co;2-9.