PMID- 19050877
OWN - NLM
STAT- MEDLINE
DCOM- 20090813
LR  - 20211020
IS  - 1619-7089 (Electronic)
IS  - 1619-7070 (Linking)
VI  - 36
IP  - 4
DP  - 2009 Apr
TI  - Impact of intracoronary injection of mononuclear bone marrow cells in acute 
      myocardial infarction on left ventricular perfusion and function: a 6-month 
      follow-up gated 99mTc-MIBI single-photon emission computed tomography study.
PG  - 587-93
LID - 10.1007/s00259-008-0988-6 [doi]
AB  - PURPOSE: We investigated the impact of intracoronary injection of autologous 
      mononuclear bone marrow cells (BMC) in patients with acute ST elevation 
      myocardial infarction (STEMI) on left ventricular volumes, global and regional 
      systolic function and myocardial perfusion. METHODS: The study included 39 
      patients with first anterior STEMI treated successfully with primary percutaneous 
      coronary intervention. They were randomly assigned to the treatment group or the 
      control group in a 2:1 ratio. The patients underwent baseline gated single-photon 
      emission computed tomography (G-SPECT) 3-10 days after STEMI with quantitative 
      and qualitative analysis of left ventricular perfusion and systolic function. On 
      the following day, patients from the BMC treatment group were subjected to bone 
      marrow aspiration, mononuclear BMC isolation and intracoronary injection. No 
      placebo procedure was performed in the control group. G-SPECT was repeated 6 
      months after STEMI. RESULTS: Baseline and follow-up G-SPECT studies were 
      available for 36 patients. At 6 months in the BMC group we observed a 
      significantly enhanced improvement in the mean extent of the perfusion defect, 
      the left ventricular perfusion score index, the infarct area perfusion score and 
      the infarct area wall motion score index compared to the control group (p = 
      0.01-0.04). However, the changes in left ventricular volume, ejection fraction 
      and the left ventricular wall motion score index as well as the relative changes 
      in the infarct area wall motion score index did not differ significantly between 
      the groups. CONCLUSION: Intracoronary injection of autologous mononuclear BMC in 
      patients with STEMI improves myocardial perfusion at 6 months. The benefit in 
      infarct area systolic function is less pronounced and there is no apparent 
      improvement of global left ventricular systolic function.
FAU - Lipiec, Piotr
AU  - Lipiec P
AD  - 2nd Department of Cardiology, Medical University of Lodz, Lodz, Poland. 
      lipiec@ptkardio.pl
FAU - Krzeminska-Pakula, Maria
AU  - Krzeminska-Pakula M
FAU - Plewka, Michal
AU  - Plewka M
FAU - Kusmierek, Jacek
AU  - Kusmierek J
FAU - Plachcinska, Anna
AU  - Plachcinska A
FAU - Szuminski, Remigiusz
AU  - Szuminski R
FAU - Robak, Tadeusz
AU  - Robak T
FAU - Korycka, Anna
AU  - Korycka A
FAU - Kasprzak, Jaroslaw D
AU  - Kasprzak JD
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20081129
PL  - Germany
TA  - Eur J Nucl Med Mol Imaging
JT  - European journal of nuclear medicine and molecular imaging
JID - 101140988
RN  - 971Z4W1S09 (Technetium Tc 99m Sestamibi)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bone Marrow Cells/cytology/*metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Ventricles/pathology
MH  - Humans
MH  - Leukocytes, Mononuclear/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*pathology
MH  - Myocardium/pathology
MH  - Prognosis
MH  - Technetium Tc 99m Sestamibi/*pharmacology
MH  - Tomography, Emission-Computed, Single-Photon/*methods
MH  - *Ventricular Function, Left
EDAT- 2008/12/04 09:00
MHDA- 2009/08/14 09:00
CRDT- 2008/12/04 09:00
PHST- 2008/07/15 00:00 [received]
PHST- 2008/10/09 00:00 [accepted]
PHST- 2008/12/04 09:00 [pubmed]
PHST- 2009/08/14 09:00 [medline]
PHST- 2008/12/04 09:00 [entrez]
AID - 10.1007/s00259-008-0988-6 [doi]
PST - ppublish
SO  - Eur J Nucl Med Mol Imaging. 2009 Apr;36(4):587-93. doi: 
      10.1007/s00259-008-0988-6. Epub 2008 Nov 29.