PMID- 19051350
OWN - NLM
STAT- MEDLINE
DCOM- 20090106
LR  - 20101118
IS  - 0192-415X (Print)
IS  - 0192-415X (Linking)
VI  - 36
IP  - 5
DP  - 2008
TI  - Molecular basis for cold-intolerant yang-deficient constitution of traditional 
      Chinese medicine.
PG  - 827-34
AB  - Based on the theory of constitution of Traditional Chinese Medicine (TCM), the 
      human population can be classified into nine constitutions including a balanced 
      constitution and eight unbalanced constitutions (Yang-deficient, Yin-deficient, 
      Qi-deficient, Phlegm-wetness, Wetness-heat, Stagnant blood, Depressed, and 
      Inherited special constitutions). Generally, unbalanced constitutions are more 
      susceptible to certain diseases than balanced constitutions. However, whether 
      such constitution classification has modern genetic and biochemical basis is 
      poorly understood. Here we examined gene expression profiles in peripheral white 
      blood cells from eight individuals with Yang-deficient constitutions and six 
      individuals with balanced constitutions using Affymetrix U133 plus 2.0 expression 
      array. Based on a q < 0.05 and fold-change > or = 2 cutoff, we have identified 
      that 785 genes are up-regulated and 954 genes are down-regulated in 
      Yang-deficient constitution compared to a balanced constitution. Importantly, we 
      found that the expression of thyroid hormone receptor beta (TRbeta) and several 
      key nuclear receptor coactivators including steroid receptor coactivator 1 
      (SRC1), steroid receptor coactivator 3 (SRC3), cAMP-response element-binding 
      protein (CREB) binding protein (CBP) and Mediator is significantly decreased. 
      Such decreased expression of TR transcription complex may lead to impaired 
      thermogenesis, providing a molecular explanation of the main symptom associated 
      with Yang-deficient constitution, cold intolerance. Future studies are needed to 
      validate these gene expression changes in additional populations and address the 
      underlying mechanisms for differential gene expression.
FAU - Wang, Qi
AU  - Wang Q
AD  - Center for Studies in Constitution Research of Traditional Chinese Medicine, 
      School of Basic Medicine, Beijing University of Chinese Medicine, 11 Bei San Huan 
      East Road, Beijing, China. wangq@bucm.edu.cn
FAU - Yao, Shilin
AU  - Yao S
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Am J Chin Med
JT  - The American journal of Chinese medicine
JID - 7901431
SB  - IM
MH  - Adult
MH  - China
MH  - Cold Temperature
MH  - Female
MH  - *Gene Expression Profiling
MH  - Gene Expression Regulation
MH  - Humans
MH  - Male
MH  - *Medicine, Chinese Traditional
MH  - Oligonucleotide Array Sequence Analysis
MH  - *Thermosensing
MH  - Transcription, Genetic
MH  - Yin Deficiency/*genetics
EDAT- 2008/12/04 09:00
MHDA- 2009/01/07 09:00
CRDT- 2008/12/04 09:00
PHST- 2008/12/04 09:00 [pubmed]
PHST- 2009/01/07 09:00 [medline]
PHST- 2008/12/04 09:00 [entrez]
AID - S0192415X08006272 [pii]
AID - 10.1142/S0192415X08006272 [doi]
PST - ppublish
SO  - Am J Chin Med. 2008;36(5):827-34. doi: 10.1142/S0192415X08006272.