PMID- 19052387
OWN - NLM
STAT- MEDLINE
DCOM- 20090326
LR  - 20191111
IS  - 1998-4138 (Electronic)
IS  - 1998-4138 (Linking)
VI  - 4
IP  - 4
DP  - 2008 Oct-Dec
TI  - Modeling correlation indices between bladder and Foley's catheter balloon dose 
      with CT-based planning using limited CT slices in intracavitary brachytherapy for 
      carcinoma of cervix.
PG  - 156-63
AB  - PURPOSE: To derive and validate an index to correlate the bladder dose with the 
      catheter balloon dose using limited computed tomography (CT) slices. MATERIALS 
      AND METHODS: Applicator geometry reconstructed from orthogonal radiographs were 
      back-projected on CT images of the same patients for anatomy-based dosimetric 
      evaluation. The correlation indices derived using power function of the catheter 
      balloon dose and the bladder volume dose were validated in 31 patients with 
      cervical cancer. RESULTS: There was significant correlation between International 
      Commission on Radiation Units (ICRU)-38 balloon reference dose (Dr) and the dose 
      received by 25% bladder volume (D(25)) (P< 0.0001). Significant correlation was 
      also found between the reference dose of mid-balloon point (D(rm)) and the dose 
      to D(25) (P < 0.0001). Average percentage difference [100 x (observed index - 
      expected index)/ expected index] of observed value of I'25 (index for the dose to 
      D25 bladder with respect to mid-balloon reference point) from that of expected 
      value was 0.52%, when the index was modeled with reference dose alone. Similarly 
      the average percentage difference for I'10cc (index for the dose to 10 cc volume 
      of bladder with respect to mid balloon point) was 0.84%. When this index was 
      modeled with absolute bladder volume and reference dose, standard deviation of 
      the percentage difference between observed and expected index for D(rm) reduced 
      by approximately 2% when compared to D(r). CONCLUSION: For clinical applications, 
      correlation index modeled with reference dose and volume predicts dose to 
      absolute volume of bladder. Correlation index modeled with reference dose gives a 
      good estimate of dose to relative bladder volume. From our study, we found D(rm) 
      to be a better indicator of bladder dose than D(r).
FAU - Oinam, Arun S
AU  - Oinam AS
AD  - Department of Radiotherapy, Postgraduate Institute of Medical Education and 
      Research, Chandigarh, India. oarunsingh@rediffmail.com
FAU - Goda, Jayant Sastri
AU  - Goda JS
FAU - Dubey, Sidharth
AU  - Dubey S
FAU - Bhardwaj, Anup
AU  - Bhardwaj A
FAU - Patel, Firuza D
AU  - Patel FD
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Cancer Res Ther
JT  - Journal of cancer research and therapeutics
JID - 101249598
SB  - IM
MH  - Biopsy
MH  - Brachytherapy/*methods
MH  - Catheterization
MH  - Female
MH  - Humans
MH  - Prospective Studies
MH  - Radiography/methods
MH  - Radiometry/*methods
MH  - Radiotherapy Dosage
MH  - Radiotherapy Planning, Computer-Assisted
MH  - Reproducibility of Results
MH  - Scattering, Radiation
MH  - Tomography, X-Ray Computed/*methods
MH  - Urinary Bladder/*pathology
MH  - Uterine Cervical Neoplasms/*diagnosis/*radiotherapy
EDAT- 2008/12/05 09:00
MHDA- 2009/03/27 09:00
CRDT- 2008/12/05 09:00
PHST- 2008/12/05 09:00 [pubmed]
PHST- 2009/03/27 09:00 [medline]
PHST- 2008/12/05 09:00 [entrez]
AID - 10.4103/0973-1482.44285 [doi]
PST - ppublish
SO  - J Cancer Res Ther. 2008 Oct-Dec;4(4):156-63. doi: 10.4103/0973-1482.44285.