PMID- 19052866
OWN - NLM
STAT- MEDLINE
DCOM- 20090810
LR  - 20211020
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 54
IP  - 9
DP  - 2009 Sep
TI  - Adipose tissue: the new endocrine organ? A review article.
PG  - 1847-56
LID - 10.1007/s10620-008-0585-3 [doi]
AB  - Fat is either white or brown, the latter being found principally in neonates. 
      White fat, which comprises adipocytes, pre-adipocytes, macrophages, endothelial 
      cells, fibroblasts, and leukocytes, actively participates in hormonal and 
      inflammatory systems. Adipokines include hormones such as leptin, adiponectin, 
      visfatin, apelin, vaspin, hepcidine, chemerin, omentin, and inflammatory 
      cytokines, including tumor necrosis factor alpha (TNF), monocyte chemoattractant 
      protein-1 (MCP-1), and plasminogen activator protein (PAI). Multiple roles in 
      metabolic and inflammatory responses have been assigned to adipokines; this 
      review describes the molecular actions and clinical significance of the more 
      important adipokines. The array of adipokines evidences diverse roles for adipose 
      tissue, which looms large in the mediators of inflammation and metabolism. For 
      this reason, treating obesity is more than a reduction of excess fat; it is also 
      the treatment of obesity's comorbidities, many of which will some day be treated 
      by drugs that counteract derangements induced by adipokine excesses.
FAU - Wozniak, Susan E
AU  - Wozniak SE
AD  - Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, 
      USA.
FAU - Gee, Laura L
AU  - Gee LL
FAU - Wachtel, Mitchell S
AU  - Wachtel MS
FAU - Frezza, Eldo E
AU  - Frezza EE
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20081204
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Adipokines)
RN  - 0 (Chemokines)
SB  - IM
MH  - Adipokines/*metabolism
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Chemokines/metabolism
MH  - Endocrine System/metabolism
MH  - Humans
MH  - Inflammation/metabolism
RF  - 87
EDAT- 2008/12/05 09:00
MHDA- 2009/08/11 09:00
CRDT- 2008/12/05 09:00
PHST- 2008/08/20 00:00 [received]
PHST- 2008/10/13 00:00 [accepted]
PHST- 2008/12/05 09:00 [pubmed]
PHST- 2009/08/11 09:00 [medline]
PHST- 2008/12/05 09:00 [entrez]
AID - 10.1007/s10620-008-0585-3 [doi]
PST - ppublish
SO  - Dig Dis Sci. 2009 Sep;54(9):1847-56. doi: 10.1007/s10620-008-0585-3. Epub 2008 
      Dec 4.