PMID- 19056904
OWN - NLM
STAT- MEDLINE
DCOM- 20090430
LR  - 20090216
IS  - 1537-1719 (Electronic)
IS  - 0737-4038 (Linking)
VI  - 26
IP  - 3
DP  - 2009 Mar
TI  - Comparative and functional characterization of intragenic tandem repeats in 10 
      Aspergillus genomes.
PG  - 591-602
LID - 10.1093/molbev/msn277 [doi]
AB  - Intragenic tandem repeats (ITRs) are consecutive repeats of three or more 
      nucleotides found in coding regions. ITRs are the underlying cause of several 
      human genetic diseases and have been associated with phenotypic variation, 
      including pathogenesis, in several clades of the tree of life. We have examined 
      the evolution and functional role of ITRs in 10 genomes spanning the fungal genus 
      Aspergillus, a clade of relevance to medicine, agriculture, and industry. We 
      identified several hundred ITRs in each of the species examined. ITR content 
      varied extensively between species, with an average 79% of ITRs unique to a given 
      species. For the fraction of conserved ITR regions, sequence comparisons within 
      species and between close relatives revealed that they were highly variable. 
      ITR-containing proteins were evolutionarily less conserved, compositionally 
      distinct, and overrepresented for domains associated with cell-surface 
      localization and function relative to the rest of the proteome. Furthermore, ITRs 
      were preferentially found in proteins involved in transcription, cellular 
      communication, and cell-type differentiation but were underrepresented in 
      proteins involved in metabolism and energy. Importantly, although ITRs were 
      evolutionarily labile, their functional associations appeared. To be remarkably 
      conserved across eukaryotes. Fungal ITRs likely participate in a variety of 
      developmental processes and cell-surface-associated functions, suggesting that 
      their contribution to fungal lifestyle and evolution may be more general than 
      previously assumed.
FAU - Gibbons, John G
AU  - Gibbons JG
AD  - Department of Biological Sciences, Vanderbilt University, Nashville, USA.
FAU - Rokas, Antonis
AU  - Rokas A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081204
PL  - United States
TA  - Mol Biol Evol
JT  - Molecular biology and evolution
JID - 8501455
RN  - 0 (Fungal Proteins)
SB  - IM
MH  - Aspergillus/*genetics
MH  - Cell Communication
MH  - Cell Differentiation
MH  - Conserved Sequence
MH  - Evolution, Molecular
MH  - Fungal Proteins/*genetics/physiology
MH  - *Genome, Fungal
MH  - Metabolism
MH  - Proteomics
MH  - *Tandem Repeat Sequences
MH  - Transcription, Genetic
EDAT- 2008/12/06 09:00
MHDA- 2009/05/01 09:00
CRDT- 2008/12/06 09:00
PHST- 2008/12/06 09:00 [pubmed]
PHST- 2009/05/01 09:00 [medline]
PHST- 2008/12/06 09:00 [entrez]
AID - msn277 [pii]
AID - 10.1093/molbev/msn277 [doi]
PST - ppublish
SO  - Mol Biol Evol. 2009 Mar;26(3):591-602. doi: 10.1093/molbev/msn277. Epub 2008 Dec 
      4.