PMID- 19057654
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211020
IS  - 1752-0371 (Electronic)
IS  - 1752-0363 (Print)
IS  - 1752-0363 (Linking)
VI  - 2
IP  - 4
DP  - 2008
TI  - Biomarkers of HIV Immune Reconstitution Inflammatory Syndrome.
PG  - 349-361
AB  - Dysregulation of the immune system drives HIV pathogenesis. As we develop new 
      ways to treat HIV and AIDS, we encounter new clinical ramifications of our 
      treatment on regulatory components of the immune system. HIV-associated Immune 
      Reconstitution Inflammatory Syndrome (IRIS) occurs after initiation of 
      anti-retroviral therapy (ART) with inappropriate and dysbalanced restoration of 
      the immune system resulting in pathologic inflammatory reactions with significant 
      morbidity. IRIS is most commonly associated with latent, occult, or past 
      infections, including tuberculosis, Cryptococcus neoformans, and Mycobacterium 
      avium-complex. We discuss common clinical presentations, new diagnostic 
      modalities, current hypotheses of IRIS pathogenesis, and future directions of 
      IRIS-related research, focusing on the identification of biomarkers that can be 
      used to predict and diagnose IRIS.
FAU - Bonham, Shuli
AU  - Bonham S
AD  - Division of Infectious Disease & International Medicine, Department of Medicine, 
      University of Minnesota, Minneapolis, MN.
FAU - Meya, David B
AU  - Meya DB
FAU - Bohjanen, Paul R
AU  - Bohjanen PR
FAU - Boulware, David R
AU  - Boulware DR
LA  - eng
GR  - L30 AI066779-02/AI/NIAID NIH HHS/United States
GR  - L30 AI066779/AI/NIAID NIH HHS/United States
GR  - T32 AI055433/AI/NIAID NIH HHS/United States
GR  - K23 AI073192/AI/NIAID NIH HHS/United States
GR  - K12 RR023247-02/RR/NCRR NIH HHS/United States
GR  - K12 RR023247/RR/NCRR NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - Biomark Med
JT  - Biomarkers in medicine
JID - 101312535
PMC - PMC2593143
MID - NIHMS60645
COIS- Conflicts of Interest: No conflicts of interest exist.
EDAT- 2008/12/06 09:00
MHDA- 2008/12/06 09:01
PMCR- 2008/12/03
CRDT- 2008/12/06 09:00
PHST- 2008/12/06 09:00 [pubmed]
PHST- 2008/12/06 09:01 [medline]
PHST- 2008/12/06 09:00 [entrez]
PHST- 2008/12/03 00:00 [pmc-release]
AID - 10.2217/17520363.2.4.349 [doi]
PST - ppublish
SO  - Biomark Med. 2008;2(4):349-361. doi: 10.2217/17520363.2.4.349.