PMID- 19058578
OWN - NLM
STAT- MEDLINE
DCOM- 20090217
LR  - 20081208
IS  - 0125-1562 (Print)
IS  - 0125-1562 (Linking)
VI  - 39
IP  - 5
DP  - 2008 Sep
TI  - Genetic characterization of nonstructural genes of H5N1 avian influenza viruses 
      isolated in Thailand in 2004-2005.
PG  - 837-47
AB  - The outbreak of highly pathogenic avian influenza (HPAI) viruses has severely 
      disrupted poultry production and trade. Humans have been infected with HPAI H5N1 
      viruses and many have died. The nonstructural (NS) proteins of the virus are a 
      factor that determines virulence. In this report, 80 NS genes of H5N1 HPAI 
      viruses isolated from Thailand were completely sequenced and phylogenically 
      analyzed. The percentages of identity and variable site NS1 genes were similar to 
      NS2/nuclear export protein (NEP) genes. All NS1 genes from the samples were 
      located in allelic group A. The NS1 and NS2/NEP proteins possess 225 and 121 
      amino acids, respectively. All NS1 protein samples had five amino acid deletions 
      typical of avian influenza viruses isolated since 2002. An amino acid 
      substitution at position 92 (G92E) of the NS1 protein, known to promote the 
      inhibition of host immune responses, was also found in the samples.
FAU - Suwannakhon, Narutchala
AU  - Suwannakhon N
AD  - Faculty of Medical Sciences, Naresuan University, Phitsanulok, Thailand.
FAU - Pookorn, Sarutsawadee
AU  - Pookorn S
FAU - Sanguansermsri, Donruedee
AU  - Sanguansermsri D
FAU - Chamnanpood, Chanpen
AU  - Chamnanpood C
FAU - Chamnanpood, Pornchai
AU  - Chamnanpood P
FAU - Wongvilairat, Rosarin
AU  - Wongvilairat R
FAU - Pongcharoen, Sutatip
AU  - Pongcharoen S
FAU - Niumsup, Pannika R
AU  - Niumsup PR
FAU - Kunthalert, Duangkamol
AU  - Kunthalert D
FAU - Sanguansermsri, Phanchana
AU  - Sanguansermsri P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Thailand
TA  - Southeast Asian J Trop Med Public Health
JT  - The Southeast Asian journal of tropical medicine and public health
JID - 0266303
RN  - 0 (INS1 protein, influenza virus)
RN  - 0 (Viral Nonstructural Proteins)
RN  - 0 (Virulence Factors)
SB  - IM
MH  - Animals
MH  - Genome, Viral
MH  - Influenza A Virus, H5N1 Subtype/*genetics/*isolation & purification
MH  - Influenza in Birds/*virology
MH  - Phylogeny
MH  - Polymerase Chain Reaction
MH  - Poultry
MH  - Sequence Analysis, DNA
MH  - Thailand/epidemiology
MH  - Viral Nonstructural Proteins/*genetics
MH  - Virulence Factors/*genetics
EDAT- 2008/12/09 09:00
MHDA- 2009/02/20 09:00
CRDT- 2008/12/09 09:00
PHST- 2008/12/09 09:00 [pubmed]
PHST- 2009/02/20 09:00 [medline]
PHST- 2008/12/09 09:00 [entrez]
PST - ppublish
SO  - Southeast Asian J Trop Med Public Health. 2008 Sep;39(5):837-47.