PMID- 19059902
OWN - NLM
STAT- MEDLINE
DCOM- 20090729
LR  - 20220409
IS  - 1939-4640 (Electronic)
IS  - 0196-3635 (Linking)
VI  - 30
IP  - 3
DP  - 2009 May-Jun
TI  - Sperm and embryo analysis in a carrier of supernumerary inv dup(15) marker 
      chromosome.
PG  - 233-9
LID - 10.2164/jandrol.108.006783 [doi]
AB  - We identified a small, paternally inherited, supernumerary marker chromosome, inv 
      dup(15), in a phenotypically normal and normozoospermic male from a couple with 
      reproductive problems. Sperm analysis by fluorescence in situ hybridization 
      (FISH) showed that the marker was present in 26% of sperm nuclei. The disomy 15 
      was 10 times higher than in normal control donors. FISH analysis for aneuploidies 
      of the other chromosomes showed an increase in nondisjunction of chromosome 21. 
      We also examined 24 embryos by preimplantation genetic diagnosis, and 10 embryos 
      (41.7%) contained the marker. This report provides information about inheritance 
      of inv dup(15) from a male carrier.
FAU - Oracova, Eva
AU  - Oracova E
AD  - Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
FAU - Musilova, Petra
AU  - Musilova P
FAU - Kopecna, Olga
AU  - Kopecna O
FAU - Rybar, Roman
AU  - Rybar R
FAU - Vozdova, Miluse
AU  - Vozdova M
FAU - Vesela, Katerina
AU  - Vesela K
FAU - Rubes, Jiri
AU  - Rubes J
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081204
PL  - United States
TA  - J Androl
JT  - Journal of andrology
JID - 8106453
SB  - IM
MH  - Adult
MH  - Chromosomes, Human, Pair 15/*genetics
MH  - Embryo, Mammalian
MH  - Female
MH  - Heterozygote
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infertility, Male/*genetics
MH  - Male
MH  - Pedigree
MH  - Pregnancy
MH  - *Spermatozoa
MH  - Uniparental Disomy/*genetics
EDAT- 2008/12/09 09:00
MHDA- 2009/07/30 09:00
CRDT- 2008/12/09 09:00
PHST- 2008/12/09 09:00 [pubmed]
PHST- 2009/07/30 09:00 [medline]
PHST- 2008/12/09 09:00 [entrez]
AID - jandrol.108.006783 [pii]
AID - 10.2164/jandrol.108.006783 [doi]
PST - ppublish
SO  - J Androl. 2009 May-Jun;30(3):233-9. doi: 10.2164/jandrol.108.006783. Epub 2008 
      Dec 4.