PMID- 19061716
OWN - NLM
STAT- MEDLINE
DCOM- 20090122
LR  - 20220330
IS  - 1097-6744 (Electronic)
IS  - 0002-8703 (Print)
IS  - 0002-8703 (Linking)
VI  - 156
IP  - 5
DP  - 2008 Nov
TI  - The partial pressure of resting end-tidal carbon dioxide predicts major cardiac 
      events in patients with systolic heart failure.
PG  - 982-8
LID - 10.1016/j.ahj.2008.06.024 [doi]
AB  - BACKGROUND: The resting partial pressure of end-tidal carbon dioxide (Petco2) has 
      been shown to reflect cardiac performance in acute care settings in patients with 
      heart failure (HF). The purpose of the present study was to compare the 
      prognostic ability of the partial pressure of Petco2 at rest to other commonly 
      collected resting variables in patients with systolic HF. METHODS: A total of 353 
      patients (mean age 58.6+/-13.7, 72% male) with systolic HF were included in this 
      study. All patients underwent cardiopulmonary exercise testing where New York 
      Heart Association (NYHA) class, resting Petco2, peak oxygen consumption, and the 
      minute ventilation/carbon dioxide production slope were determined. Subjects were 
      then followed for major cardiac events (mortality, left ventricular assist device 
      implantation implantation, urgent heart transplantation). RESULTS: There were 104 
      major cardiac events during the 23.6+/-17.0-month tracking period. Multivariate 
      Cox regression analysis revealed NYHA class (chi2 28.7, P<.001), left ventricular 
      ejection fraction (residual chi2 21.7, P<.001), and resting Petco2 (residual chi2 
      14.1, P<.001) were all prognostically significant and retained in the regression. 
      In a separate Cox regression analysis, left ventricular ejection fraction 
      (residual chi2 8.8, P=.003), NYHA class (residual chi2 7.7, P=.005), and resting 
      Petco2 (residual chi2 5.7, P=.02) added prognostic value to the minute 
      ventilation/carbon dioxide production slope (chi2 26.0, P<.001). CONCLUSION: 
      Resting Petco2 can be noninvasively collected from subjects in a short period, at 
      a low cost, and with no risk or discomfort to the patient. Given the prognostic 
      value demonstrated in the present study, the clinical assessment of resting 
      Petco2 in the HF population may be warranted.
FAU - Arena, Ross
AU  - Arena R
AD  - Department of Physical Therapy, Virginia Commonwealth University, Health Sciences 
      Campus, Richmond, VA 23298-0224, USA. raarena@vcu.edu
FAU - Myers, Jonathan
AU  - Myers J
FAU - Abella, Joshua
AU  - Abella J
FAU - Pinkstaff, Sherry
AU  - Pinkstaff S
FAU - Brubaker, Peter
AU  - Brubaker P
FAU - Moore, Brian
AU  - Moore B
FAU - Kitzman, Dalane
AU  - Kitzman D
FAU - Peberdy, Mary Ann
AU  - Peberdy MA
FAU - Bensimhon, Daniel
AU  - Bensimhon D
FAU - Chase, Paul
AU  - Chase P
FAU - Guazzi, Marco
AU  - Guazzi M
LA  - eng
GR  - P60AG10484/AG/NIA NIH HHS/United States
GR  - IK6 RX002477/RX/RRD VA/United States
GR  - P30 AG021332/AG/NIA NIH HHS/United States
GR  - R37AG18915/AG/NIA NIH HHS/United States
GR  - R37 AG018915/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, N.I.H., Extramural
DEP - 20080827
PL  - United States
TA  - Am Heart J
JT  - American heart journal
JID - 0370465
RN  - 142M471B3J (Carbon Dioxide)
SB  - IM
MH  - Carbon Dioxide/*metabolism
MH  - Female
MH  - Heart Diseases/*etiology
MH  - Heart Failure, Systolic/*complications/*metabolism
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Partial Pressure
MH  - Predictive Value of Tests
PMC - PMC3730838
MID - NIHMS77965
EDAT- 2008/12/09 09:00
MHDA- 2009/01/23 09:00
PMCR- 2013/08/01
CRDT- 2008/12/09 09:00
PHST- 2008/03/15 00:00 [received]
PHST- 2008/06/10 00:00 [accepted]
PHST- 2008/12/09 09:00 [pubmed]
PHST- 2009/01/23 09:00 [medline]
PHST- 2008/12/09 09:00 [entrez]
PHST- 2013/08/01 00:00 [pmc-release]
AID - S0002-8703(08)00546-2 [pii]
AID - 10.1016/j.ahj.2008.06.024 [doi]
PST - ppublish
SO  - Am Heart J. 2008 Nov;156(5):982-8. doi: 10.1016/j.ahj.2008.06.024. Epub 2008 Aug 
      27.