PMID- 1906417
OWN - NLM
STAT- MEDLINE
DCOM- 19910822
LR  - 20210915
IS  - 0016-6731 (Print)
IS  - 0016-6731 (Linking)
VI  - 128
IP  - 2
DP  - 1991 Jun
TI  - The independent distorting ability of the Enhancer of Segregation Distortion, 
      E(SD), in Drosophila melanogaster.
PG  - 339-56
AB  - Segregation distortion is a meiotic drive system, discovered in wild populations, 
      in which males heterozygous for an SD chromosome and a sensitive SD+ homolog 
      transmit the SD chromosome almost exclusively. SD represents a complex of three 
      closely linked loci in the centromeric region of chromosome 2: Sd, the 
      Segregation distorter gene; E(SD), the Enhancer of Segregation Distortion, 
      required for full expression of drive; and Rsp, the target for the action of Sd, 
      existing in a continuum of states classifiable into sensitive (Rsps) and 
      insensitive (Rspi). In an SD/SD+ male which is Sd E(SD) Rspi/Sd+ E(SD)+ Rsps, the 
      Sd and E(SD) elements act jointly to induce the dysfunction of those spermatids 
      receiving the Rsps chromosome. By manipulating the number of copies and the 
      position of the Enhancer region, I demonstrated that: (1) E(SD), whether in its 
      normal position or translocated to the Y chromosome, is able to enhance the 
      degree of Sd-caused distortion in a dosage-dependent manner; (2) even in the 
      absence of Sd, the E(SD) allele in two doses can cause significant distortion, in 
      Sd+ or Df(Sd)-bearing genotypes; (3) quantitative differences among Enhancers of 
      different sources suggest allelic variation at E(SD), which could account at 
      least in part for differences among wild SD chromosomes in strength of 
      distortion; (4) E(SD)/E(SD)-mediated distortion, like that of Sd, is directed at 
      the Rsp target, whether Rsp is on the second or the Y chromosome; (5) E(SD), like 
      Sd, is suppressed by an unlinked dominant suppressor of SD action. These results 
      show that E(SD) is independently capable of acting on Rsp and is not a simple 
      modifier of the action of Sd. E(SD) provides an example of a trans-acting gene 
      embedded in heterochromatin that can interact with another heterochromatic gene, 
      Rsp, as well as parallel the effect of a euchromatic gene, Sd.
FAU - Temin, R G
AU  - Temin RG
AD  - Laboratory of Genetics, University of Wisconsin-Madison 53706.
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Genetics
JT  - Genetics
JID - 0374636
SB  - IM
GS  - E(SD)
GS  - Rsp
GS  - Sd
MH  - Animals
MH  - Crosses, Genetic
MH  - Drosophila melanogaster/*genetics
MH  - *Enhancer Elements, Genetic
MH  - Female
MH  - Genetic Variation
MH  - Male
MH  - Meiosis/*genetics
MH  - Suppression, Genetic
MH  - Y Chromosome
PMC - PMC1204472
EDAT- 1991/06/01 00:00
MHDA- 1991/06/01 00:01
PMCR- 1991/09/01
CRDT- 1991/06/01 00:00
PHST- 1991/06/01 00:00 [pubmed]
PHST- 1991/06/01 00:01 [medline]
PHST- 1991/06/01 00:00 [entrez]
PHST- 1991/09/01 00:00 [pmc-release]
AID - 1282339 [pii]
AID - 10.1093/genetics/128.2.339 [doi]
PST - ppublish
SO  - Genetics. 1991 Jun;128(2):339-56. doi: 10.1093/genetics/128.2.339.