PMID- 19065130
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20090424
LR  - 20211020
IS  - 1745-8331 (Electronic)
IS  - 1745-8323 (Linking)
VI  - 5
IP  - 2
DP  - 2009 Feb
TI  - Is matching for human leukocyte antigen-DR beneficial in pediatric kidney 
      transplantation?
PG  - 70-1
LID - 10.1038/ncpneph1017 [doi]
AB  - This Practice Point commentary discusses the findings and limitations of a report 
      by Gritsch et al., in which the authors concluded that human leukocyte antigen 
      (HLA)-DR-mismatched kidneys from deceased donors aged 35 years or less are 
      suitable for use in pediatric patients. We highlight the issues to be considered 
      before adopting such an allocation policy. Gritsch et al. reported that the 
      5-year survival rates of grafts with zero HLA-DR mismatches were identical to 
      those of grafts that were completely mismatched for HLA-DR; however, the report 
      did not provide information about the immunosuppressive regimens used or the 
      frequency of rejection episodes and their treatment. Children who receive 
      HLA-DR-mismatched kidneys will ultimately be exposed to more-intensive 
      immunosuppression in order to overcome the potentially increased risks of acute 
      rejection, graft failure and sensitization. In spite of recent improvements in 
      immunosuppressive therapy, we believe that HLA matching remains crucial for the 
      survival of kidney transplants.
FAU - Ghoneim, Mohamed A
AU  - Ghoneim MA
AD  - Urology and Nephrology Center, Mansoura University, Mansoura, Egypt. 
      ghoneimma@yahoo.com
FAU - Refaie, Ayman F
AU  - Refaie AF
LA  - eng
PT  - Comment
PT  - Journal Article
DEP - 20081209
PL  - England
TA  - Nat Clin Pract Nephrol
JT  - Nature clinical practice. Nephrology
JID - 101261800
CON - Am J Transplant. 2008 Oct;8(10):2056-61. PMID: 18839440
EDAT- 2008/12/10 09:00
MHDA- 2008/12/10 09:01
CRDT- 2008/12/10 09:00
PHST- 2008/11/05 00:00 [received]
PHST- 2008/11/13 00:00 [accepted]
PHST- 2008/12/10 09:00 [pubmed]
PHST- 2008/12/10 09:01 [medline]
PHST- 2008/12/10 09:00 [entrez]
AID - ncpneph1017 [pii]
AID - 10.1038/ncpneph1017 [doi]
PST - ppublish
SO  - Nat Clin Pract Nephrol. 2009 Feb;5(2):70-1. doi: 10.1038/ncpneph1017. Epub 2008 
      Dec 9.