PMID- 19065524
OWN - NLM
STAT- MEDLINE
DCOM- 20090325
LR  - 20221207
IS  - 1003-9406 (Print)
IS  - 1003-9406 (Linking)
VI  - 25
IP  - 6
DP  - 2008 Dec
TI  - [Association of matrix metalloproteinase-3 serum level and the promoter 5A/6A 
      polymorphism of the MMP-3 gene with atherosclerotic cerebral infarction].
PG  - 653-6
AB  - OBJECTIVE: To investigate the association of matrix metalloproteinase-3 (MMP-3) 
      serum level and the promoter 5A/6A polymorphism of the MMP-3 gene with 
      atherosclerotic cerebral infarction (ACI) in a Chinese Han population. METHODS: 
      Two hundred and fifteen patients with acute ACI from the Department of Neurology 
      of Taizhou Hospital and 226 healthy controls were included in the study. Serum 
      MMP-3 level was measured by enzyme-linked immunosorbent assay (ELISA). Genotype 
      was determined by polymerase chain reaction-restriction fragment length 
      polymorphism (PCR-RFLP) for the common 5A/6A functional promoter polymorphism of 
      the MMP-3 gene. RESULTS: The genotype distribution of the MMP-3 promoter 5A/6A 
      polymorphism between the ACI patients group and the control group was 
      significantly different (chi (2)= 9.389, P= 0.002). The frequencies of the 5A 
      allele were 14.2% and 7.7% in the ACI patients group and the control group 
      respectively (chi (2)= 9.430, P= 0.002). Serum level of MMP-3 in the ACI patients 
      group was significantly higher than that in the control group (t= 24.867, P= 
      0.000). Among the ACI patients group, serum MMP-3 levels also had significant 
      difference between the 5A/6A+ 5A/5A and the 6A/6A genotype (t= 2.057, P= 0.041). 
      CONCLUSION: The present findings suggest that serum level of MMP-3 obviously 
      increased within 48 hours of ischemic stroke and the genetic polymorphism of 
      5A/6A in the MMP-3 promoter is associated with ACI and MMP-3 expression in the 
      Chinese Han population.
FAU - Huang, Xiaoya
AU  - Huang X
AD  - Department of Neurology, the Affiliated Taizhou Hospital, Wenzhou Medical 
      College, Taizhou, Zhejiang 317000, P. R. China.
FAU - Zhu, Min
AU  - Zhu M
FAU - Jin, Xiaoping
AU  - Jin X
FAU - Zhang, Danhong
AU  - Zhang D
FAU - Wang, Linzhi
AU  - Wang L
FAU - Ye, Zusen
AU  - Ye Z
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi
JT  - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese 
      journal of medical genetics
JID - 9425197
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Asian People/genetics
MH  - Case-Control Studies
MH  - Cerebral Infarction/*blood/complications/*genetics
MH  - Ethnicity/genetics
MH  - Female
MH  - Gene Frequency
MH  - Genotype
MH  - Humans
MH  - Intracranial Arteriosclerosis/*blood/complications/*genetics
MH  - Male
MH  - Matrix Metalloproteinase 3/*blood/*genetics
MH  - Middle Aged
MH  - *Polymorphism, Genetic
MH  - Promoter Regions, Genetic/*genetics
EDAT- 2008/12/10 09:00
MHDA- 2009/03/26 09:00
CRDT- 2008/12/10 09:00
PHST- 2008/12/10 09:00 [pubmed]
PHST- 2009/03/26 09:00 [medline]
PHST- 2008/12/10 09:00 [entrez]
AID - 940625140 [pii]
PST - ppublish
SO  - Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2008 Dec;25(6):653-6.