PMID- 19065832
OWN - NLM
STAT- MEDLINE
DCOM- 20090123
LR  - 20161020
IS  - 0869-8139 (Print)
IS  - 0869-8139 (Linking)
VI  - 94
IP  - 10
DP  - 2008 Oct
TI  - [Comparative analysis of 1-desamino-arginine-vasotocin, 
      1-desamino-1-monocarba-arginine-vasotocin and desmopressin antidiuretic effect in 
      rats].
PG  - 1191-4
AB  - This study was carried out to investigate the antidiuretic efficacy of 
      1-desamino-arginine-vasotocin (1-dAVT), 1-desamino-1-monocarba-arginine-vasotocin 
      (1-dlmcAVT) in comparison with desmopressin in Wistar rats. Intramuscular 
      injection of 0.0001 nmole/100 g body weight of desmopressin or synthesized 
      analogues of arginine-vasotocin 5 % in the water loading resulted in significant 
      reduction of urinary flow (p < 0.001) and later removed the diuresis maximum. The 
      most expressed decrease of water excretion which was correlated with the 
      diminished diuresis (r = -0.78,p < 0.001) was observed after injection of 0.0001 
      nmole/100 g body weight desmopressin. The equivalent increase of water 
      reabsorbtion was induced by 0.00005 nmole/100 g body weight 1-dlmcAVT or 
      desmopressin. The differences between excretion of osmotically active substances, 
      sodium or potassium in the action of 1-dAVT, 1 -d-lmcAVT and desmopressin was not 
      revealed.
FAU - Bogolepova, A E
AU  - Bogolepova AE
FAU - Zaitseva, K V
AU  - Zaitseva KV
LA  - rus
PT  - Comparative Study
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Russia (Federation)
TA  - Ross Fiziol Zh Im I M Sechenova
JT  - Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova
JID - 9715665
RN  - 0 (Antidiuretic Agents)
RN  - 0 (Oxytocics)
RN  - 059QF0KO0R (Water)
RN  - 9NEZ333N27 (Sodium)
RN  - ENR1LLB0FP (Deamino Arginine Vasopressin)
RN  - RWP5GA015D (Potassium)
RN  - W6S6URY8OF (Vasotocin)
SB  - IM
MH  - Animals
MH  - Antidiuretic Agents/*pharmacology
MH  - Body Weight/drug effects
MH  - Deamino Arginine Vasopressin/*pharmacology
MH  - Female
MH  - Oxytocics/pharmacology
MH  - Potassium/urine
MH  - Rats
MH  - Rats, Wistar
MH  - Sodium/urine
MH  - Vasotocin/*analogs & derivatives/*pharmacology
MH  - Water/metabolism
MH  - Water-Electrolyte Balance/*drug effects
EDAT- 2008/12/11 09:00
MHDA- 2009/01/24 09:00
CRDT- 2008/12/11 09:00
PHST- 2008/12/11 09:00 [pubmed]
PHST- 2009/01/24 09:00 [medline]
PHST- 2008/12/11 09:00 [entrez]
PST - ppublish
SO  - Ross Fiziol Zh Im I M Sechenova. 2008 Oct;94(10):1191-4.