PMID- 19067396
OWN - NLM
STAT- MEDLINE
DCOM- 20100323
LR  - 20141120
IS  - 1520-6017 (Electronic)
IS  - 0022-3549 (Linking)
VI  - 98
IP  - 8
DP  - 2009 Aug
TI  - Evaluation of spray congealing as technique for the preparation of highly loaded 
      solid lipid microparticles containing the sunscreen agent, avobenzone.
PG  - 2759-69
LID - 10.1002/jps.21636 [doi]
AB  - Solid lipid microparticles (SLMs) loaded with high amounts of the sunscreen 
      agent, butyl methoxydibenzoylmethane (avobenzone) were prepared in order to 
      reduce its photoinstability. The microparticles were produced, using carnauba wax 
      as lipidic material and phosphatidylcholine as the surfactant, by the classical 
      melt dispersion method or the spray congealing technique with pneumatic atomizer. 
      The sunscreen agent loading was 40.1-48.5% (w/w), with no significant differences 
      between the production methods. However, release studies indicated that spray 
      congealing enabled a more efficient modulation of avobenzone release from the 
      SLMs (26% of encapsulated avobenzone released after 2 h as compared to 60% for 
      melt dispersion). The photoprotective efficacy of the SLMs was evaluated after 
      their introduction in a model cream. A statistically significant decrease of the 
      light-induced degradation of avobenzone was obtained by the SLMs prepared by the 
      melt dispersion procedure (the extent of degradation was 38.6 +/- 3.6% for 
      nonencapsulated avobenzone and 32.1 +/- 4.3% for the microparticle-entrapped 
      sunscreen). On the other hand, the SLMs produced by spray congealing achieved a 
      more marked reduction in avobenzone photodecomposition to 15.4 +/- 4.1%. 
      Therefore, the spray congealing technique was superior to the classical melt 
      dispersion method for rapid and solvent free production of SLMs with a high 
      avobenzone loading capacity.
CI  - Copyright 2009 Wiley-Liss, Inc.
FAU - Albertini, Beatrice
AU  - Albertini B
AD  - Department of Pharmaceutical Sciences, University of Bologna, via S. Donato 19, 
      Bologna, Italy.
FAU - Mezzena, Matteo
AU  - Mezzena M
FAU - Passerini, Nadia
AU  - Passerini N
FAU - Rodriguez, Lorenzo
AU  - Rodriguez L
FAU - Scalia, Santo
AU  - Scalia S
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Pharm Sci
JT  - Journal of pharmaceutical sciences
JID - 2985195R
RN  - 0 (Capsules)
RN  - 0 (Chalcones)
RN  - 0 (Drug Carriers)
RN  - 0 (Lipids)
RN  - 0 (Propiophenones)
RN  - 0 (Sunscreening Agents)
RN  - G63QQF2NOX (avobenzone)
SB  - IM
MH  - Capsules
MH  - Chalcones/administration & dosage/*chemical synthesis
MH  - Chemistry, Pharmaceutical/*methods
MH  - Drug Carriers/administration & dosage/chemical synthesis
MH  - Drug Evaluation, Preclinical/methods
MH  - Lipids/administration & dosage/*chemical synthesis
MH  - Particle Size
MH  - Photolysis
MH  - Propiophenones
MH  - Sunscreening Agents/administration & dosage/*chemical synthesis
MH  - X-Ray Diffraction/methods
EDAT- 2008/12/11 09:00
MHDA- 2010/03/24 06:00
CRDT- 2008/12/11 09:00
PHST- 2008/12/11 09:00 [pubmed]
PHST- 2010/03/24 06:00 [medline]
PHST- 2008/12/11 09:00 [entrez]
AID - S0022-3549(16)33030-1 [pii]
AID - 10.1002/jps.21636 [doi]
PST - ppublish
SO  - J Pharm Sci. 2009 Aug;98(8):2759-69. doi: 10.1002/jps.21636.