PMID- 19068240
OWN - NLM
STAT- MEDLINE
DCOM- 20090428
LR  - 20090130
IS  - 1537-1891 (Print)
IS  - 1537-1891 (Linking)
VI  - 50
IP  - 3-4
DP  - 2009 Mar-Apr
TI  - Femoral artery diameter and arteriogenic cytokines in healthy women.
PG  - 104-9
LID - 10.1016/j.vph.2008.11.005 [doi]
AB  - Animal studies have identified monocyte chemoattractive protein-1 (MCP-1) and 
      vascular endothelial growth factor (VEGF) as critical mediators of arterial 
      diameter enlargement in response to chronic increases in blood flow 
      (arteriogenesis). Furthermore, cellular studies have shown that the shear 
      stresses resulting from increased blood flow stimulate synthesis of MCP-1, which 
      in turn stimulates synthesis of VEGF. The purpose of this study was to determine 
      if these mechanisms are evident in healthy women. Resting femoral artery diameter 
      and blood flow, lean leg mass, MCP-1 and VEGF concentrations, and aerobic 
      capacity were measured in 34 healthy women along with plasma concentrations of 
      lipids associated with cardiovascular disease risk. Femoral artery diameter was 
      independently related to metabolically active (lean) leg mass (b=0.41, P=0.008) 
      and aerobic capacity (b=0.45, P=0.004). Plasma MCP-1 correlated negatively with 
      the ratio of femoral artery diameter to lean leg mass (b=-0.42, P=0.009) and 
      positively with serum triglycerides (b=0.46, P=0.005). Plasma VEGF exhibited 
      similar correlations and strongly correlated with MCP-1 (R=0.92, P<0.0001). The 
      results indicate that circulating MCP-1 and VEGF concentrations are associated 
      with both arteriogenic and atherogenic stimuli in healthy women.
FAU - Cannon, Joseph G
AU  - Cannon JG
AD  - Medical College of Georgia, Department of Biomedical and Radiological 
      Technologies, Augusta, GA 30912, United States. jcannon@mcg.edu
FAU - Sabatier, Manning J
AU  - Sabatier MJ
FAU - Marinik, Elaina L
AU  - Marinik EL
FAU - Schwark, Earl H
AU  - Schwark EH
FAU - Haddow, Sara
AU  - Haddow S
FAU - Cortez-Cooper, Miriam
AU  - Cortez-Cooper M
FAU - Bergeron, Michael F
AU  - Bergeron MF
FAU - Sloan, Gloria J
AU  - Sloan GJ
FAU - McCully, Kevin K
AU  - McCully KK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081127
PL  - United States
TA  - Vascul Pharmacol
JT  - Vascular pharmacology
JID - 101130615
RN  - 0 (Chemokine CCL2)
RN  - 0 (Vascular Endothelial Growth Factor A)
SB  - IM
MH  - Adult
MH  - Chemokine CCL2/*blood
MH  - Female
MH  - Femoral Artery/*anatomy & histology/*physiology
MH  - Humans
MH  - Leg/anatomy & histology/blood supply
MH  - Physical Fitness
MH  - Vascular Endothelial Growth Factor A/*blood
EDAT- 2008/12/11 09:00
MHDA- 2009/04/29 09:00
CRDT- 2008/12/11 09:00
PHST- 2008/07/18 00:00 [received]
PHST- 2008/10/30 00:00 [revised]
PHST- 2008/11/14 00:00 [accepted]
PHST- 2008/12/11 09:00 [pubmed]
PHST- 2009/04/29 09:00 [medline]
PHST- 2008/12/11 09:00 [entrez]
AID - S1537-1891(08)00146-8 [pii]
AID - 10.1016/j.vph.2008.11.005 [doi]
PST - ppublish
SO  - Vascul Pharmacol. 2009 Mar-Apr;50(3-4):104-9. doi: 10.1016/j.vph.2008.11.005. 
      Epub 2008 Nov 27.