PMID- 1906912
OWN - NLM
STAT- MEDLINE
DCOM- 19910823
LR  - 20231213
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 164
IP  - 2
DP  - 1991 Aug
TI  - Plasma neutrophil-activating peptide-1/interleukin-8 and neutrophil elastase in a 
      primate bacteremia model.
PG  - 383-8
AB  - A hyperdynamic sepsis model was set up in seven adult baboons to evaluate 
      neutrophil-activating peptide-1/interleukin (IL)-8 (NAP-1/IL-8), IL-1 beta, IL-6, 
      tumor necrosis factor-alpha (TNF alpha), and IFN-gamma in plasma. By continuous 
      intravenous administration of 10(10) cfu/kg live Escherichia coli over 8 h with 
      additional infusion therapy (less than or equal to 50 ml/kg/h), endotoxin plasma 
      levels of 2.7-22.3 ng/ml were observed. In plasma the kinetics of NAP-1/IL-8 and 
      IL-6 were similar to those of IL-1 at the end of the experiment (8 h) (peak 
      median values, 34, 4197, and 230 ng/ml, respectively). Differences were greatest 
      for IL-6. Monocyte activation during sepsis was confirmed by elevated plasma 
      neopterin levels (91-139 mumol/mmol of creatine). Granulocyte activation was 
      evident from both incipient neutropenia and the massive release of neutrophil 
      elastase into the plasma as measured by a new immunoassay (peak level, 374 
      ng/ml). Thus, in primate bacteremia, early TNF release is followed by a 
      concomitant increase of NAP-1/IL-8 with plasma kinetics similar to those of IL-6 
      and IL-1 and accompanied by massive activation of neutrophils.
FAU - Redl, H
AU  - Redl H
AD  - Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, 
      Austria.
FAU - Schlag, G
AU  - Schlag G
FAU - Bahrami, S
AU  - Bahrami S
FAU - Schade, U
AU  - Schade U
FAU - Ceska, M
AU  - Ceska M
FAU - Stutz, P
AU  - Stutz P
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Endotoxins)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0 (Biopterins)
RN  - 670-65-5 (Neopterin)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.4.21.36 (Pancreatic Elastase)
RN  - EC 3.4.21.37 (Leukocyte Elastase)
SB  - IM
MH  - Animals
MH  - Biopterins/analogs & derivatives/blood
MH  - Disease Models, Animal
MH  - Endotoxins/blood
MH  - Escherichia coli Infections/*blood/enzymology
MH  - Interferon-gamma/blood
MH  - Interleukin-1/blood
MH  - Interleukin-6/blood
MH  - Interleukin-8/*blood
MH  - Leukocyte Elastase
MH  - Male
MH  - Neopterin
MH  - Pancreatic Elastase/*blood
MH  - Papio
MH  - Sepsis/*blood/enzymology
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1991/08/01 00:00
MHDA- 1991/08/01 00:01
CRDT- 1991/08/01 00:00
PHST- 1991/08/01 00:00 [pubmed]
PHST- 1991/08/01 00:01 [medline]
PHST- 1991/08/01 00:00 [entrez]
AID - 10.1093/infdis/164.2.383 [doi]
PST - ppublish
SO  - J Infect Dis. 1991 Aug;164(2):383-8. doi: 10.1093/infdis/164.2.383.