PMID- 19069167
OWN - NLM
STAT- MEDLINE
DCOM- 20090128
LR  - 20131121
IS  - 1881-6096 (Print)
IS  - 1881-6096 (Linking)
VI  - 60
IP  - 11
DP  - 2008 Nov
TI  - [Beta2-glycoprotein I polymorphism].
PG  - 1333-8
AB  - Antiphopholipid syndrome (APS) is a major cause of ischemic stroke in young 
      adults. In our study, stroke patients with antiphospholipid antibodies (APL) were 
      significantly younger and were more likely to be women than stroke patients 
      without APL. Valvular heart disease, neurological complications, and 
      hematological disorders were more frequent in the APL-positive group. The mean 
      value of thrombin-antithrombin III complex was significantly lower in the 
      APL-positive group. beta2-Glyoprotein I (beta2-GPI) is the antigen primarily 
      responsible for APL. At the DNA level, 4 different types of allelic polymorphisms 
      have been detected in beta2-GPI. The allele at position 247 has codes for either 
      valine (V) or leucine (L), which results in genotypic expression of VV, VL, or 
      LL. In our study, the V and VL genotypes were more frequent in patients with 
      cerebral infarction than in normal controls. The VL genotype was more frequent 
      among patients aged less than 60 years than in those aged more than 60 years. The 
      mean values of beta-thromboglobulin and platelet factor 4 in patients with the VL 
      genotype were significantly higher than those with the LL genotype. The results 
      suggested that V247 beta2-GPI allele is one of the genetic risk factors for the 
      development of cerebral infarction through platelet activation.
FAU - Terashi, Hiromi
AU  - Terashi H
AD  - Department of Neurology, Tokyo Wemens University, School of Medicine, 8-1 
      Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
FAU - Hashimoto, Shiori
AU  - Hashimoto S
FAU - Uchiyama, Shinichiro
AU  - Uchiyama S
LA  - jpn
PT  - English Abstract
PT  - Journal Article
PT  - Review
PL  - Japan
TA  - Brain Nerve
JT  - Brain and nerve = Shinkei kenkyu no shinpo
JID - 101299709
RN  - 0 (Antibodies, Antiphospholipid)
RN  - 0 (beta 2-Glycoprotein I)
RN  - 0 (beta-Thromboglobulin)
RN  - 37270-94-3 (Platelet Factor 4)
RN  - GMW67QNF9C (Leucine)
RN  - HG18B9YRS7 (Valine)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Antibodies, Antiphospholipid/genetics
MH  - Antiphospholipid Syndrome/genetics
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Leucine/genetics
MH  - Male
MH  - Middle Aged
MH  - Platelet Factor 4
MH  - *Polymorphism, Genetic
MH  - Risk Factors
MH  - Stroke/*genetics
MH  - Valine/genetics
MH  - beta 2-Glycoprotein I/*genetics
MH  - beta-Thromboglobulin
RF  - 22
EDAT- 2008/12/17 09:00
MHDA- 2009/01/29 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/01/29 09:00 [medline]
PST - ppublish
SO  - Brain Nerve. 2008 Nov;60(11):1333-8.