PMID- 19071223
OWN - NLM
STAT- MEDLINE
DCOM- 20090428
LR  - 20211020
IS  - 1095-9572 (Electronic)
IS  - 1053-8119 (Print)
IS  - 1053-8119 (Linking)
VI  - 45
IP  - 1
DP  - 2009 Mar 1
TI  - Dissociable neural representations of future reward magnitude and delay during 
      temporal discounting.
PG  - 143-50
LID - 10.1016/j.neuroimage.2008.11.004 [doi]
AB  - In temporal discounting, individuals often prefer smaller immediate rewards to 
      larger delayed rewards, implying a trade off between the magnitude and delay of 
      future rewards. While recent functional magnetic resonance imaging (fMRI) 
      investigations of temporal discounting have generated conflicting findings, no 
      studies have focused on whether distinct neural substrates respond to the 
      magnitude and delay of future rewards. Combining a novel, temporally distributed 
      discounting task with event-related fMRI, we found that while nucleus accumbens 
      (NAcc), mesial prefrontal cortical (MPFC), and posterior cingulate cortical (PCC) 
      activation positively correlated with future reward magnitude, dorsolateral 
      prefrontal cortical (DLPFC) and posterior parietal cortical (PPC) activation 
      negatively correlated with future reward delay. Further, more impulsive 
      individuals showed diminished NAcc activation to the magnitude of future rewards 
      and greater deactivations to delays of future rewards in the MPFC, DLPFC, and 
      PPC. These findings suggest that while mesolimbic dopamine projection regions 
      show greater sensitivity to the magnitude of future rewards, lateral cortical 
      regions show greater (negative) sensitivity to the delay of future rewards, 
      potentially reconciling different neural accounts of temporal discounting.
FAU - Ballard, Kacey
AU  - Ballard K
AD  - Department of Psychology, Stanford University, CA 94305, USA. 
      kballard@stanford.edu
FAU - Knutson, Brian
AU  - Knutson B
LA  - eng
GR  - R21 AG030778-01/AG/NIA NIH HHS/United States
GR  - P30 AG024957/AG/NIA NIH HHS/United States
GR  - AG024957/AG/NIA NIH HHS/United States
GR  - P30 AG024957-05/AG/NIA NIH HHS/United States
GR  - R21 AG030778-02/AG/NIA NIH HHS/United States
GR  - R03 DA020615-01/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20081124
PL  - United States
TA  - Neuroimage
JT  - NeuroImage
JID - 9215515
SB  - IM
MH  - Adult
MH  - Brain/*physiology
MH  - Brain Mapping/*methods
MH  - Choice Behavior/*physiology
MH  - Decision Making/*physiology
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - *Reward
MH  - Time Factors
PMC - PMC2685201
MID - NIHMS100400
EDAT- 2008/12/17 09:00
MHDA- 2009/04/29 09:00
PMCR- 2010/03/01
CRDT- 2008/12/17 09:00
PHST- 2008/08/24 00:00 [received]
PHST- 2008/11/05 00:00 [revised]
PHST- 2008/11/06 00:00 [accepted]
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/04/29 09:00 [medline]
PHST- 2010/03/01 00:00 [pmc-release]
AID - S1053-8119(08)01209-3 [pii]
AID - 10.1016/j.neuroimage.2008.11.004 [doi]
PST - ppublish
SO  - Neuroimage. 2009 Mar 1;45(1):143-50. doi: 10.1016/j.neuroimage.2008.11.004. Epub 
      2008 Nov 24.