PMID- 19071658
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20121002
LR  - 20081216
IS  - 1873-3573 (Electronic)
IS  - 0039-9140 (Linking)
VI  - 72
IP  - 2
DP  - 2007 Apr 30
TI  - Quantification of tripdiolide in human whole blood by liquid chromatography 
      coupled with atmospheric pressure chemical ionization tandem mass spectrometry.
PG  - 582-6
LID - 10.1016/j.talanta.2006.11.030 [doi]
AB  - A liquid chromatographic-tandem mass spectrometric (LC-MS/MS) assay was developed 
      and validated to determine tripdiolide in human whole blood using dexamethasone 
      acetate as an internal standard (I.S.). Liquid-liquid extraction with ethyl 
      acetate was used to isolate them from the biological matrix. Detection was 
      performed on a mass spectrometer coupled with a negative atmospheric pressure 
      chemical ionization (APCI) in the multiple-reaction monitoring (MRM) mode. The 
      calibration curve was linear (r(2)=0.9973) in the concentration range of 
      0.5-100.0ng/mL in human whole blood with a lower limit of quantification of 
      0.5ng/mL. Intra-day and inter-day relative standard deviations (R.S.D.s) were 
      less than 7.0 and 10.1%, respectively. Extraction recoveries of tripdiolide 
      ranged from 80.5 to 90.1%. This assay can be used to determine trace tripdiolide 
      in human whole blood.
FAU - Jin, Micong
AU  - Jin M
AD  - Department of Chemical and Biochemical Engineering, Zhejiang University, Hangzhou 
      310027, China; Ningbo Municipal Center for Disease Control and Prevention, Ningbo 
      315010, China.
FAU - Ouyang, Xiaokun
AU  - Ouyang X
FAU - Yang, Yiwen
AU  - Yang Y
FAU - Ren, Qilong
AU  - Ren Q
LA  - eng
PT  - Journal Article
DEP - 20061218
PL  - Netherlands
TA  - Talanta
JT  - Talanta
JID - 2984816R
EDAT- 2007/04/30 00:00
MHDA- 2007/04/30 00:01
CRDT- 2008/12/17 09:00
PHST- 2006/08/21 00:00 [received]
PHST- 2006/11/16 00:00 [revised]
PHST- 2006/11/18 00:00 [accepted]
PHST- 2008/12/17 09:00 [entrez]
PHST- 2007/04/30 00:00 [pubmed]
PHST- 2007/04/30 00:01 [medline]
AID - S0039-9140(06)00766-1 [pii]
AID - 10.1016/j.talanta.2006.11.030 [doi]
PST - ppublish
SO  - Talanta. 2007 Apr 30;72(2):582-6. doi: 10.1016/j.talanta.2006.11.030. Epub 2006 
      Dec 18.