PMID- 19072398
OWN - NLM
STAT- MEDLINE
DCOM- 20090306
LR  - 20131121
IS  - 1747-4132 (Electronic)
IS  - 1747-4124 (Linking)
VI  - 2
IP  - 4
DP  - 2008 Aug
TI  - Rabeprazole: a second-generation proton pump inhibitor in the treatment of 
      acid-related disease.
PG  - 509-22
LID - 10.1586/17474124.2.4.509 [doi]
AB  - Rabeprazole is a proton pump inhibitor (PPI) presenting a very advantageous 
      pharmacodynamic and pharmacokinetic profile over older PPIs. In particular, this 
      drug has a very fast onset of action, due to a short activation time and a very 
      high pKa, and may therefore be defined as a 'second generation' PPI. The aim of 
      this article is to provide an update on the pharmacology and clinical profile of 
      rabeprazole and its use in acid-related disorders, with a particular focus on its 
      role in gastroesophageal reflux disease; in the treatment and prevention of 
      duodenal and gastric ulcers and Zollinger-Ellison syndrome; in the therapy of the 
      extraesophageal manifestations of gastroesophageal reflux disease (in particular 
      the respiratory and ear, nose and throat ones); and in the eradication of 
      Helicobacter pylori.
FAU - Pallotta, Stefano
AU  - Pallotta S
AD  - University of Milan, Via GB Grassi, 74, 20157 Milano, MI, Italy. 
      stefanopallotta@interfree.it
FAU - Pace, Fabio
AU  - Pace F
FAU - Marelli, Silvia
AU  - Marelli S
LA  - eng
PT  - Journal Article
PL  - England
TA  - Expert Rev Gastroenterol Hepatol
JT  - Expert review of gastroenterology & hepatology
JID - 101278199
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 32828355LL (Rabeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles/chemistry/pharmacokinetics/*therapeutic 
      use
MH  - Barrett Esophagus/drug therapy
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Humans
MH  - Proton Pump Inhibitors/chemistry/pharmacokinetics/*therapeutic use
MH  - Rabeprazole
MH  - Stomach Ulcer/drug therapy
MH  - Zollinger-Ellison Syndrome/drug therapy
EDAT- 2008/12/17 09:00
MHDA- 2009/03/07 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/03/07 09:00 [medline]
AID - 10.1586/17474124.2.4.509 [doi]
PST - ppublish
SO  - Expert Rev Gastroenterol Hepatol. 2008 Aug;2(4):509-22. doi: 
      10.1586/17474124.2.4.509.