PMID- 19073516
OWN - NLM
STAT- MEDLINE
DCOM- 20090212
LR  - 20211203
IS  - 1525-7304 (Print)
IS  - 1525-7304 (Linking)
VI  - 9
IP  - 6
DP  - 2008 Nov
TI  - The role of targeting mammalian target of rapamycin in lung cancer.
PG  - 340-5
LID - 10.3816/CLC.2008.n.049 [doi]
AB  - The expression of mammalian target of rapamycin (mTOR) might be upregulated by 
      various mechanisms in lung cancer pathogenesis, and its activity might be 
      modulated by pathways related to tobacco-mediated carcinogenesis. Furthermore, 
      preclinical data suggest an antitumor effect in lung cancer from a class of 
      agents that antagonize the mTOR pathway. Consistent with this, initial clinical 
      trials of mTOR inhibitors suggest some activity in the setting of both 
      non-small-cell lung carcinoma and small-cell lung carcinoma. Herein, we explore 
      the relationship of mTOR to lung carcinogenesis and further describe clinical 
      trials of mTOR inhibitors alone and in combination with chemotherapeutic and 
      targeted agents.
FAU - Pal, Sumanta Kumar
AU  - Pal SK
AD  - Department of Medical Oncology and Experimental Therapeutics, City of Hope 
      Comprehensive Cancer Center, Duarte, CA 91010, USA.
FAU - Figlin, Robert A
AU  - Figlin RA
FAU - Reckamp, Karen L
AU  - Reckamp KL
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Clin Lung Cancer
JT  - Clinical lung cancer
JID - 100893225
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Protein Kinase Inhibitors)
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.1.1 (MTOR protein, human)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Antineoplastic Agents/*therapeutic use
MH  - Carcinoma, Non-Small-Cell Lung/drug therapy/metabolism
MH  - Carcinoma, Small Cell/drug therapy/metabolism
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Lung Neoplasms/*drug therapy/metabolism
MH  - Protein Kinase Inhibitors/*therapeutic use
MH  - Protein Kinases/*metabolism
MH  - TOR Serine-Threonine Kinases
RF  - 49
EDAT- 2008/12/17 09:00
MHDA- 2009/02/13 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/02/13 09:00 [medline]
AID - S1525-7304(11)70238-8 [pii]
AID - 10.3816/CLC.2008.n.049 [doi]
PST - ppublish
SO  - Clin Lung Cancer. 2008 Nov;9(6):340-5. doi: 10.3816/CLC.2008.n.049.