PMID- 19073620
OWN - NLM
STAT- MEDLINE
DCOM- 20090216
LR  - 20141120
IS  - 1460-2091 (Electronic)
IS  - 0305-7453 (Linking)
VI  - 63
IP  - 2
DP  - 2009 Feb
TI  - Pharmacokinetics of ceftiofur hydrochloride in pigs infected with porcine 
      reproductive and respiratory syndrome virus.
PG  - 369-73
LID - 10.1093/jac/dkn496 [doi]
AB  - OBJECTIVES: To compare the pharmacokinetic profile of ceftiofur hydrochloride 
      (ceftiofur) administered intramuscularly at 3 mg/kg body weight (BW) in pigs 
      infected with porcine reproductive and respiratory syndrome virus (PRRSV) versus 
      clinically healthy pigs. METHODS: Sixteen 3- to 4-week-old PRRSV-negative pigs 
      were randomly assigned to two groups (A and B), with eight pigs per group. Pigs 
      in Group A were uninfected controls and pigs in Group B were intranasally 
      challenged with a PRRSV isolate of Thai origin. Pigs in both groups were 
      intramuscularly administered ceftiofur at 3 mg/kg BW at 7 days post-infection. 
      Blood samples were serially collected up to 72 h post-injection. Plasma was 
      analysed for ceftiofur and its related metabolites using HPLC. Pharmacokinetic 
      parameters of ceftiofur were calculated based on non-compartmental analysis. 
      RESULTS: Pharmacokinetic parameters of ceftiofur revealed statistically 
      significant differences (P < 0.01) in maximum concentration (C(max)), AUC, volume 
      of distribution at the terminal phase over bioavailability (V(z)/F), clearance 
      over bioavailability (CL/F) and the terminal half-life (t(1/2z)) between Groups A 
      and B. PRRSV-infected pigs had a V(z)/F and CL/F of ceftiofur significantly 
      higher than in the non-infected pigs (116% increase in V(z)/F, 234% increase in 
      CL/F). The C(max) and AUC of the infected pigs decreased by 54% and 70%, 
      respectively, compared with the non-infected pigs. The t(1/2z) of the infected 
      pigs and the non-infected pigs was 13.1 and 21.0 h, respectively. CONCLUSIONS: 
      The pharmacokinetic profile of ceftiofur is altered in PRRSV-infected pigs due to 
      the decreased plasma ceftiofur concentration compared with clinically healthy 
      pigs.
FAU - Tantituvanont, Angkana
AU  - Tantituvanont A
AD  - Department of Pharmacy, Faculty of Pharmaceutical Sciences, Chulalongkorn 
      University, Bangkok 10330, Thailand. t_tuvanont@hotmail.com
FAU - Yimprasert, Walaisiri
AU  - Yimprasert W
FAU - Werawatganone, Pornpen
AU  - Werawatganone P
FAU - Nilubol, Dahrit
AU  - Nilubol D
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081210
PL  - England
TA  - J Antimicrob Chemother
JT  - The Journal of antimicrobial chemotherapy
JID - 7513617
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Cephalosporins)
RN  - 83JL932I1C (ceftiofur)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents/administration & dosage/*pharmacokinetics
MH  - Area Under Curve
MH  - Biological Availability
MH  - Cephalosporins/administration & dosage/*pharmacokinetics
MH  - Chromatography, High Pressure Liquid
MH  - Half-Life
MH  - Metabolic Clearance Rate
MH  - Plasma/chemistry
MH  - *Porcine Reproductive and Respiratory Syndrome
MH  - Random Allocation
MH  - Swine
EDAT- 2008/12/17 09:00
MHDA- 2009/02/17 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/02/17 09:00 [medline]
AID - dkn496 [pii]
AID - 10.1093/jac/dkn496 [doi]
PST - ppublish
SO  - J Antimicrob Chemother. 2009 Feb;63(2):369-73. doi: 10.1093/jac/dkn496. Epub 2008 
      Dec 10.