PMID- 19073626
OWN - NLM
STAT- MEDLINE
DCOM- 20091021
LR  - 20211020
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 19
IP  - 9
DP  - 2009 Sep
TI  - Sex differences in the effects of acute and chronic stress and recovery after 
      long-term stress on stress-related brain regions of rats.
PG  - 1978-89
LID - 10.1093/cercor/bhn225 [doi]
AB  - Studies show that sex plays a role in stress-related depression, with women 
      experiencing a higher vulnerability to its effect. Two major targets of 
      antidepressants are brain-derived neurotrophic factor (BDNF) and cyclic adenosine 
      monophosphate response element-binding protein (CREB). The aim of this study was 
      to investigate the levels of CREB, phosphorylation of CREB (pCREB), and BDNF in 
      stress-related brain regions of male and female rats after stress and recovery. 
      CREB and pCREB levels were examined in CA1, CA2, CA3, paraventricular nucleus of 
      the thalamus (PVT), amygdala, anterior cingulate area, dorsal part (ACAd), and 
      infralimbic area of prefrontal cortex (PFC), whereas dentate gyrus (DG) and 
      prelimbic area (PL) of PFC were examined for BDNF levels. Our results demonstrate 
      that levels of CREB and pCREB in male CA1, CA2 and CA3, PVT, amygdala, and ACAd 
      were reduced by stress, whereas the same brain regions of female rats exhibited 
      no change. BDNF levels were decreased by chronic stress in female PL but were 
      increased by acute stress in female DG. BDNF levels in male DG and PL were found 
      not to undergo change in response to stress. Abnormalities in morphology occurred 
      after chronic stress in males but not in females. In all cases, the levels of 
      CREB, pCREB, and BDNF in recovery animals were comparable to the levels of these 
      proteins in control animals. These findings demonstrate a sexual dimorphism in 
      the molecular response to stress and suggest that these differences may have 
      important implications for potential therapeutic treatment of depression.
FAU - Lin, Yanhua
AU  - Lin Y
AD  - Department of Neuroscience, University Medical Center Groningen and University of 
      Groningen, 9700 RB Groningen, the Netherlands.
FAU - Ter Horst, Gert J
AU  - Ter Horst GJ
FAU - Wichmann, Romy
AU  - Wichmann R
FAU - Bakker, Petra
AU  - Bakker P
FAU - Liu, Aihua
AU  - Liu A
FAU - Li, Xuejun
AU  - Li X
FAU - Westenbroek, Christel
AU  - Westenbroek C
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081210
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.3.1.48 (Crebbp protein, rat)
SB  - IM
MH  - Acute Disease
MH  - Animals
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - CREB-Binding Protein
MH  - Cyclic AMP Response Element-Binding Protein/*metabolism
MH  - Female
MH  - Male
MH  - Neuronal Plasticity
MH  - Rats
MH  - Rats, Wistar
MH  - *Recovery of Function
MH  - Sex Factors
MH  - Stress, Psychological/*metabolism
MH  - Tissue Distribution
PMC - PMC2722422
EDAT- 2008/12/17 09:00
MHDA- 2009/10/22 06:00
PMCR- 2008/12/10
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/10/22 06:00 [medline]
PHST- 2008/12/10 00:00 [pmc-release]
AID - bhn225 [pii]
AID - 10.1093/cercor/bhn225 [doi]
PST - ppublish
SO  - Cereb Cortex. 2009 Sep;19(9):1978-89. doi: 10.1093/cercor/bhn225. Epub 2008 Dec 
      10.