PMID- 19074353
OWN - NLM
STAT- MEDLINE
DCOM- 20090105
LR  - 20081216
IS  - 1095-9203 (Electronic)
IS  - 0036-8075 (Linking)
VI  - 322
IP  - 5908
DP  - 2008 Dec 12
TI  - Regulation of dendritic cell migration by CD74, the MHC class II-associated 
      invariant chain.
PG  - 1705-10
LID - 10.1126/science.1159894 [doi]
AB  - Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens 
      to present to T cells. This requires two processes, antigen processing and cell 
      motility, originally thought to occur independently. We found that the major 
      histocompatibility complex II-associated invariant chain (Ii or CD74), a known 
      regulator of antigen processing, negatively regulates DC motility in vivo. By 
      using microfabricated channels to mimic the confined environment of peripheral 
      tissues, we found that wild-type DCs alternate between high and low motility, 
      whereas Ii-deficient cells moved in a faster and more uniform manner. The 
      regulation of cell motility by Ii depended on the actin-based motor protein 
      myosin II. Coupling antigen processing and cell motility may enable DCs to more 
      efficiently detect and process antigens within a defined space.
FAU - Faure-Andre, Gabrielle
AU  - Faure-Andre G
AD  - INSERM U653, Institut Curie, 12 rue Lhomond, 75005, Paris, France.
FAU - Vargas, Pablo
AU  - Vargas P
FAU - Yuseff, Maria-Isabel
AU  - Yuseff MI
FAU - Heuze, Melina
AU  - Heuze M
FAU - Diaz, Jheimmy
AU  - Diaz J
FAU - Lankar, Danielle
AU  - Lankar D
FAU - Steri, Veronica
AU  - Steri V
FAU - Manry, Jeremy
AU  - Manry J
FAU - Hugues, Stephanie
AU  - Hugues S
FAU - Vascotto, Fulvia
AU  - Vascotto F
FAU - Boulanger, Jerome
AU  - Boulanger J
FAU - Raposo, Graca
AU  - Raposo G
FAU - Bono, Maria-Rosa
AU  - Bono MR
FAU - Rosemblatt, Mario
AU  - Rosemblatt M
FAU - Piel, Matthieu
AU  - Piel M
FAU - Lennon-Dumenil, Ana-Maria
AU  - Lennon-Dumenil AM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antigens, Differentiation, B-Lymphocyte)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (invariant chain)
RN  - EC 3.4.- (Cathepsins)
RN  - EC 3.4.22.27 (cathepsin S)
RN  - EC 3.6.1.- (Myosin Type II)
SB  - IM
CIN - Science. 2008 Dec 12;322(5908):1640-1. PMID: 19074333
MH  - Animals
MH  - Antigen Presentation
MH  - Antigens, Differentiation, B-Lymphocyte/genetics/*metabolism
MH  - Cathepsins/genetics/metabolism
MH  - *Cell Movement
MH  - Dendritic Cells/*immunology/physiology
MH  - Endocytosis
MH  - Histocompatibility Antigens Class II/genetics/*metabolism
MH  - Lipopolysaccharides/immunology
MH  - Lymph Nodes/cytology/immunology
MH  - Lysosomes/metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Myosin Type II/*metabolism
MH  - Phosphorylation
EDAT- 2008/12/17 09:00
MHDA- 2009/01/06 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/01/06 09:00 [medline]
AID - 322/5908/1705 [pii]
AID - 10.1126/science.1159894 [doi]
PST - ppublish
SO  - Science. 2008 Dec 12;322(5908):1705-10. doi: 10.1126/science.1159894.