PMID- 19074534
OWN - NLM
STAT- MEDLINE
DCOM- 20100426
LR  - 20131121
IS  - 1461-7285 (Electronic)
IS  - 0269-8811 (Linking)
VI  - 24
IP  - 2
DP  - 2010 Feb
TI  - Ethanol co-administration moderates 3,4-methylenedioxymethamphetamine effects on 
      human physiology.
PG  - 165-74
LID - 10.1177/0269881108100020 [doi]
AB  - Alcohol is frequently used in combination with 3,4-methylenedioxymethamphetamine 
      (MDMA). Both drugs affect cardiovascular function, hydration and temperature 
      regulation, but may have partly opposing effects. The present study aims to 
      assess the acute physiologic effects of (co-) administration of MDMA and ethanol 
      over time. A four-way, double blind, randomized, crossover, placebo-controlled 
      study in 16 healthy volunteers (9 male and 7 female) between the ages of 18 and 
      29. MDMA (100 mg) was given orally and blood ethanol concentration was maintained 
      at pseudo-steady state levels of 0.6 per thousand by a three-hour 10% intravenous 
      ethanol clamp. Cardiovascular function, temperature and hydration measures were 
      recorded throughout the study days. Ethanol did not significantly affect 
      physiologic function, with the exception of a short lasting increase in heart 
      rate. MDMA potently increased heart rate and blood pressure and induced fluid 
      retention as well as an increase in temperature. Co-administration of ethanol 
      with MDMA did not affect cardiovascular function compared to the MDMA alone 
      condition, but attenuated the effects of MDMA on fluid retention and showed a 
      trend for attenuation of MDMA-induced temperature increase. In conclusion, 
      co-administration of ethanol and MDMA did not exacerbate physiologic effects 
      compared to all other drug conditions, and moderated some effects of MDMA alone.
FAU - Dumont, G J H
AU  - Dumont GJ
AD  - Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, 
      The Netherlands. G.J.H.Dumont@psy.umcn.nl
FAU - Kramers, C
AU  - Kramers C
FAU - Sweep, F C G J
AU  - Sweep FC
FAU - Willemsen, J J
AU  - Willemsen JJ
FAU - Touw, D J
AU  - Touw DJ
FAU - Schoemaker, R C
AU  - Schoemaker RC
FAU - van Gerven, J M A
AU  - van Gerven JM
FAU - Buitelaar, J K
AU  - Buitelaar JK
FAU - Verkes, R J
AU  - Verkes RJ
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20081212
PL  - United States
TA  - J Psychopharmacol
JT  - Journal of psychopharmacology (Oxford, England)
JID - 8907828
RN  - 0 (Hallucinogens)
RN  - 3K9958V90M (Ethanol)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Blood Pressure/drug effects
MH  - Body Temperature/drug effects
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Drug Interactions
MH  - Ethanol/administration & dosage/pharmacokinetics/*pharmacology
MH  - Female
MH  - Hallucinogens/administration & dosage/*pharmacology
MH  - Heart Rate/drug effects
MH  - Humans
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*pharmacology
MH  - Time Factors
MH  - Young Adult
EDAT- 2008/12/17 09:00
MHDA- 2010/04/27 06:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2010/04/27 06:00 [medline]
AID - 0269881108100020 [pii]
AID - 10.1177/0269881108100020 [doi]
PST - ppublish
SO  - J Psychopharmacol. 2010 Feb;24(2):165-74. doi: 10.1177/0269881108100020. Epub 
      2008 Dec 12.