PMID- 19075677
OWN - NLM
STAT- MEDLINE
DCOM- 20090204
LR  - 20211020
IS  - 1566-5240 (Print)
IS  - 1875-5666 (Electronic)
IS  - 1566-5240 (Linking)
VI  - 8
IP  - 8
DP  - 2008 Dec
TI  - Menin, histone h3 methyltransferases, and regulation of cell proliferation: 
      current knowledge and perspective.
PG  - 805-15
AB  - Menin is a tumor suppressor encoded by the MEN1 gene that is mutated in patients 
      with an inherited syndrome, multiple endocrine neoplasia type 1 (MEN1). Loss of 
      menin has potent impact on proliferation of endocrine and non-endocrine cells. 
      However, until recently little has been known as to how menin regulates cell 
      proliferation. Rapid research progress in the past several years suggests that 
      menin represses proliferation of endocrine cells yet promotes proliferation in 
      certain types of leukemia cells via interacting with various transcriptional 
      regulators. Menin interacts with histone H3 methyltransferases such as MLL (mixed 
      lineage leukemia) protein. Increasing evidence has linked the biological function 
      of menin to epigenetic histone modifications, control of the pattern of gene 
      expression, and regulation of cell proliferation in a cell type-specific manner. 
      In light of these recent findings, an emerging model suggests that menin is a 
      crucial regulator of histone modifiers by acting as a scaffold protein to 
      coordinate gene transcription and cell proliferation in a cell context-dependent 
      manner. This recent progress unravels the coordinating role of menin in 
      epigenetics and regulation of cell cycle, providing novel insights into 
      understanding regulation of beta cell functions and diabetes, as well as the 
      development and therapy of endocrine tumors and leukemia.
FAU - Wu, Xinjiang
AU  - Wu X
AD  - Abramson Family Cancer Research Institute, Department of Cancer Biology, 
      University of Pennsylvania, Philadelphia, Pennsylvania, USA.
FAU - Hua, Xianxin
AU  - Hua X
LA  - eng
GR  - R01 CA113962/CA/NCI NIH HHS/United States
GR  - R01 CA100912-04/CA/NCI NIH HHS/United States
GR  - R01 CA100912/CA/NCI NIH HHS/United States
GR  - R01 CA113962-02/CA/NCI NIH HHS/United States
GR  - R01 CA100912-03/CA/NCI NIH HHS/United States
GR  - R01 CA113962-03/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Curr Mol Med
JT  - Current molecular medicine
JID - 101093076
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein)
RN  - EC 2.1.1.- (Histone Methyltransferases)
RN  - EC 2.1.1.- (Protein Methyltransferases)
RN  - EC 2.1.1.43 (Histone-Lysine N-Methyltransferase)
SB  - IM
MH  - *Cell Proliferation
MH  - Genes, Tumor Suppressor
MH  - Histone Methyltransferases
MH  - Histone-Lysine N-Methyltransferase
MH  - Humans
MH  - Leukemia, Biphenotypic, Acute/genetics/pathology/physiopathology
MH  - Models, Biological
MH  - Multiple Endocrine Neoplasia Type 1/genetics/pathology/physiopathology
MH  - Myeloid-Lymphoid Leukemia Protein/genetics/physiology
MH  - Protein Methyltransferases/*physiology
MH  - Proto-Oncogene Proteins/genetics/*physiology
MH  - Translocation, Genetic
PMC - PMC2858577
MID - NIHMS183824
EDAT- 2008/12/17 09:00
MHDA- 2009/02/05 09:00
PMCR- 2010/04/22
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/02/05 09:00 [medline]
PHST- 2010/04/22 00:00 [pmc-release]
AID - 10.2174/156652408786733702 [doi]
PST - ppublish
SO  - Curr Mol Med. 2008 Dec;8(8):805-15. doi: 10.2174/156652408786733702.