PMID- 19076545
OWN - NLM
STAT- MEDLINE
DCOM- 20090227
LR  - 20131121
IS  - 1398-9995 (Electronic)
IS  - 0105-4538 (Linking)
VI  - 64
IP  - 1
DP  - 2009 Jan
TI  - Both allergic and nonallergic asthma are associated with increased FE(NO) levels, 
      but only in never-smokers.
PG  - 55-61
LID - 10.1111/j.1398-9995.2008.01835.x [doi]
AB  - BACKGROUND: Allergic asthma is consistently associated with increased FE(NO) 
      levels whereas divergence exists regarding the use of exhaled nitric oxide (NO) 
      as marker of inflammation in nonallergic asthma and in asthmatic smokers. The aim 
      of this study is to analyze the effect of having allergic or nonallergic asthma 
      on exhaled nitric oxide levels, with special regard to smoking history. METHODS: 
      Exhaled NO measurements were performed in 695 subjects from Turin (Italy), 
      Gothenburg and Uppsala (both Sweden). Current asthma was defined as self-reported 
      physician-diagnosed asthma with at least one asthma symptom or attack recorded 
      during the last year. Allergic status was defined by using measurements of 
      specific immunoglobulin E (IgE). Smoking history was questionnaire-assessed. 
      RESULTS: Allergic asthma was associated with 91 (60, 128) % [mean (95% CI)] 
      increase of FE(NO) while no significant association was found for nonallergic 
      asthma [6 (-17, 35) %] in univariate analysis, when compared to nonatopic healthy 
      subjects. In a multivariate analysis for never-smokers, subjects with allergic 
      asthma had 77 (27, 145) % higher FE(NO) levels than atopic healthy subjects while 
      subjects with nonallergic asthma had 97 (46, 166) % higher FE(NO) levels than 
      nonatopic healthy subjects. No significant asthma-related FE(NO) increases were 
      noted for ex- and current smokers in multivariate analysis. CONCLUSIONS: Both 
      allergic and nonallergic asthma are related to increased FE(NO) levels, but only 
      in never-smoking subjects. The limited value of FE(NO) to detect subjects with 
      asthma among ex- and current smokers suggests the predominance of a 
      noneosinophilic inflammatory phenotype of asthma among ever-smokers.
FAU - Malinovschi, A
AU  - Malinovschi A
AD  - Department of Medical Cell Biology: Integrative Physiology, Uppsala University, 
      Uppsala, Sweden.
FAU - Janson, C
AU  - Janson C
FAU - Hogman, M
AU  - Hogman M
FAU - Rolla, G
AU  - Rolla G
FAU - Toren, K
AU  - Toren K
FAU - Norback, D
AU  - Norback D
FAU - Olin, A-C
AU  - Olin AC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081205
PL  - Denmark
TA  - Allergy
JT  - Allergy
JID - 7804028
RN  - 31C4KY9ESH (Nitric Oxide)
SB  - IM
MH  - Adult
MH  - Asthma/*metabolism
MH  - Case-Control Studies
MH  - Europe
MH  - Exhalation
MH  - Female
MH  - Humans
MH  - Hypersensitivity
MH  - Inflammation
MH  - Male
MH  - Nitric Oxide/*analysis
MH  - *Respiratory Transport
MH  - Smoking
EDAT- 2008/12/17 09:00
MHDA- 2009/02/28 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/02/28 09:00 [medline]
AID - ALL1835 [pii]
AID - 10.1111/j.1398-9995.2008.01835.x [doi]
PST - ppublish
SO  - Allergy. 2009 Jan;64(1):55-61. doi: 10.1111/j.1398-9995.2008.01835.x. Epub 2008 
      Dec 5.