PMID- 19076564
OWN - NLM
STAT- MEDLINE
DCOM- 20090515
LR  - 20181201
IS  - 1399-3038 (Electronic)
IS  - 0905-6157 (Linking)
VI  - 19
IP  - 8
DP  - 2008 Dec
TI  - Is caesarean delivery associated with sensitization to food allergens and 
      IgE-mediated food allergy: a systematic review.
PG  - 682-7
LID - 10.1111/j.1399-3038.2008.00731.x [doi]
AB  - Several studies have shown differences in the composition of the gastrointestinal 
      flora of children who develop sensitization to food allergens compared with 
      non-allergic children. It has been hypothesized that changes in the gut 
      microbiota resulting from caesarean section delivery could increase a child's 
      risk of developing food allergy; however, studies examining the relationship 
      between mode of delivery and food allergy have produced conflicting results. The 
      objective of this review was to determine whether there is sufficient evidence to 
      support an association between delivery by caesarean section and the development 
      of sensitization to food allergens and immunoglobulin E (IgE) mediated food 
      allergy. Using predefined inclusion and exclusion criteria, MEDLINE and PubMed 
      were searched for studies investigating the relationship between caesarean 
      section delivery and food allergy. The information on the quality of the studies 
      and results were extracted and analysed systematically. The search identified 
      four relevant studies as per our protocol. Symptomatic food allergy was used as 
      the outcome in two studies and was found to occur more frequently in children 
      born by caesarean section in one study while the second study found no 
      association between food allergy diagnoses and mode of delivery. The other two 
      studies measured levels of food antigen-specific IgE, with both studies showing 
      an increase in sensitization to food allergens among children born by caesarean 
      section. Overall, there is evidence that the risk of developing IgE-mediated 
      sensitization to food allergens is increased among children delivered by 
      caesarean section, however further studies using objectively diagnosed food 
      allergy as the outcome are needed to verify whether this equates to an increase 
      in confirmed food allergy. Future birth cohort studies should control for the 
      effects of mode of delivery when investigating environmental modifiers of food 
      allergy.
FAU - Koplin, Jennifer
AU  - Koplin J
AD  - Murdoch Children's Research Institute and Department of Paediatrics, The 
      University of Melbourne, Victoria, Melbourne, Australia.
FAU - Allen, Katie
AU  - Allen K
FAU - Gurrin, Lyle
AU  - Gurrin L
FAU - Osborne, Nicholas
AU  - Osborne N
FAU - Tang, Mimi L K
AU  - Tang ML
FAU - Dharmage, Shyamali
AU  - Dharmage S
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
PL  - England
TA  - Pediatr Allergy Immunol
JT  - Pediatric allergy and immunology : official publication of the European Society 
      of Pediatric Allergy and Immunology
JID - 9106718
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens/*immunology
MH  - *Cesarean Section
MH  - Child, Preschool
MH  - Female
MH  - Food Hypersensitivity/*etiology/immunology
MH  - Humans
MH  - Immunoglobulin E/*blood
MH  - Infant
MH  - Risk Factors
RF  - 22
EDAT- 2008/12/17 09:00
MHDA- 2009/05/16 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/05/16 09:00 [medline]
AID - PAI731 [pii]
AID - 10.1111/j.1399-3038.2008.00731.x [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol. 2008 Dec;19(8):682-7. doi: 
      10.1111/j.1399-3038.2008.00731.x.