PMID- 19076623
OWN - NLM
STAT- MEDLINE
DCOM- 20090223
LR  - 20081216
IS  - 1529-8019 (Electronic)
IS  - 1396-0296 (Linking)
VI  - 21
IP  - 6
DP  - 2008 Nov-Dec
TI  - Microcystic adnexal carcinoma: a diagnostic and therapeutic challenge.
PG  - 452-8
LID - 10.1111/j.1529-8019.2008.00246.x [doi]
AB  - Microcystic adnexal carcinoma (MAC) is a rare cutaneous neoplasm that is often 
      diagnosed after having been present for a significant period of time. It appears 
      bland on histologic evaluation despite its locally aggressive behavior. Actual 
      skin involvement is significantly more extensive than can be determined 
      clinically and because of this, therapy is challenging. Though metastasis is 
      rare, there have been reports of both regional and distant metastatic disease. 
      Several treatment modalities have been used to date, including standard excision 
      (SE), Mohs micrographic surgery (MMS), irradiation, chemotherapy, and 
      observation. There has also been discussion in the literature regarding 
      techniques than can aid in assurance of clear margins with MMS. We review the 
      literature on MAC, including the various therapeutic options, addressing when one 
      modality may be preferable over others. In general, MMS offers the highest 
      likelihood of clear margins and cure with the fewest procedures.
FAU - Wetter, Robyn
AU  - Wetter R
AD  - Dermatology and Skin Cancer Center, Leawood, Kansas 66211, USA. 
      robynfriedman@kc.rr.com
FAU - Goldstein, Glenn D
AU  - Goldstein GD
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Dermatol Ther
JT  - Dermatologic therapy
JID - 9700070
SB  - IM
MH  - Carcinoma, Skin Appendage/diagnosis/pathology/*therapy
MH  - Humans
MH  - Mohs Surgery
MH  - Neoplasm Metastasis/pathology
MH  - Neoplasm Recurrence, Local
MH  - Skin Neoplasms/diagnosis/pathology/*therapy
MH  - Time Factors
RF  - 67
EDAT- 2008/12/17 09:00
MHDA- 2009/02/24 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/02/24 09:00 [medline]
AID - DTH246 [pii]
AID - 10.1111/j.1529-8019.2008.00246.x [doi]
PST - ppublish
SO  - Dermatol Ther. 2008 Nov-Dec;21(6):452-8. doi: 10.1111/j.1529-8019.2008.00246.x.