PMID- 19076685 OWN - NLM STAT- MEDLINE DCOM- 20090203 LR - 20081216 IS - 1365-2559 (Electronic) IS - 0309-0167 (Linking) VI - 53 IP - 6 DP - 2008 Dec TI - Annexin A1 subcellular expression in laryngeal squamous cell carcinoma. PG - 715-27 LID - 10.1111/j.1365-2559.2008.03186.x [doi] AB - AIMS: Annexin A1 (ANXA1) is a soluble cytoplasmic protein, moving to membranes when calcium levels are elevated. ANXA1 has also been shown to move to the nucleus or outside the cells, depending on tyrosine-kinase signalling, thus interfering in cytoskeletal organization and cell differentiation, mostly in inflammatory and neoplastic processes. The aim was to investigate subcellular patterns of immunohistochemical expression of ANXA1 in neoplastic and non-neoplastic samples from patients with laryngeal squamous cell carcinomas (LSCC), to elucidate the role of ANXA1 in laryngeal carcinogenesis. METHODS AND RESULTS: Serial analysis of gene expression experiments detected reduced expression of ANXA1 gene in LSCC compared with the corresponding non-neoplastic margins. Quantitative polymerase chain reaction confirmed ANXA1 low expression in 15 LSCC and eight matched normal samples. Thus, we investigated subcellular patterns of immunohistochemical expression of ANXA1 in 241 paraffin-embedded samples from 95 patients with LSCC. The results showed ANXA1 down-regulation in dysplastic, tumourous and metastatic lesions and provided evidence for the progressive migration of ANXA1 from the nucleus towards the membrane during laryngeal tumorigenesis. CONCLUSIONS: ANXA1 dysregulation was observed early in laryngeal carcinogenesis, in intra-epithelial neoplasms; it was not found related to prognostic parameters, such as nodal metastases. FAU - Alves, V A F AU - Alves VA AD - Department of Pathology, School of Medicine, USP, Sao Paulo, Brazil. FAU - Nonogaki, S AU - Nonogaki S FAU - Cury, P M AU - Cury PM FAU - Wunsch-Filho, V AU - Wunsch-Filho V FAU - de Carvalho, M B AU - de Carvalho MB FAU - Michaluart-Junior, P AU - Michaluart-Junior P FAU - Moyses, R A AU - Moyses RA FAU - Curioni, O A AU - Curioni OA FAU - Figueiredo, D L A AU - Figueiredo DL FAU - Scapulatempo-Neto, C AU - Scapulatempo-Neto C FAU - Parra, E R AU - Parra ER FAU - Polachini, G M AU - Polachini GM FAU - Silistino-Souza, R AU - Silistino-Souza R FAU - Oliani, S M AU - Oliani SM FAU - Silva-Junior, W A AU - Silva-Junior WA FAU - Nobrega, F G AU - Nobrega FG CN - Head and Neck Genome Project/GENCAPO FAU - Tajara, E H AU - Tajara EH FAU - Zago, M A AU - Zago MA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Histopathology JT - Histopathology JID - 7704136 RN - 0 (Annexin A1) SB - IM MH - Adult MH - Aged MH - Aged, 80 and over MH - Annexin A1/analysis/genetics/*metabolism MH - Blotting, Western MH - Carcinoma, Squamous Cell/*metabolism/pathology MH - Female MH - Gene Expression MH - Humans MH - Immunohistochemistry MH - Laryngeal Neoplasms/*metabolism/pathology MH - Male MH - Middle Aged FIR - Cury, P M IR - Cury PM FIR - de Carvalho, M B IR - de Carvalho MB FIR - Dias-Neto, E IR - Dias-Neto E FIR - Figueiredo, D L A IR - Figueiredo DL FIR - Fukuyama, E E IR - Fukuyama EE FIR - Gois-Filho, J F IR - Gois-Filho JF FIR - Leopoldino, A M IR - Leopoldino AM FIR - Mamede, R C M IR - Mamede RC FIR - Michaluart-Junior, P IR - Michaluart-Junior P FIR - Moreira-Filho, C A IR - Moreira-Filho CA FIR - Moyses, R A IR - Moyses RA FIR - Nobrega, F G IR - Nobrega FG FIR - Nobrega, M P IR - Nobrega MP FIR - Nunes, F D IR - Nunes FD FIR - Ojopi, E P B IR - Ojopi EP FIR - Okamoto, O K IR - Okamoto OK FIR - Serafini, L N IR - Serafini LN FIR - Severino, P IR - Severino P FIR - Silva, A M A IR - Silva AM FIR - Silva, W A Jr IR - Silva WA Jr FIR - Silveira, N J F IR - Silveira NJ FIR - Souza, S C O M IR - Souza SC FIR - Tajara, E H IR - Tajara EH FIR - Wunsch-Filho, V IR - Wunsch-Filho V FIR - Zago, M A IR - Zago MA FIR - Amar, A IR - Amar A FIR - Arap, S S IR - Arap SS FIR - Araujo, N S S IR - Araujo NS FIR - Araujo-Filho, V IR - Araujo-Filho V FIR - Barbieri, R B IR - Barbieri RB FIR - Bandeira, C M IR - Bandeira CM FIR - Bastos, A U IR - Bastos AU FIR - Bogossian, A P IR - Bogossian AP FIR - Braconi, M A IR - Braconi MA FIR - Brandao, L G IR - Brandao LG FIR - Brandao, R M IR - Brandao RM FIR - Canto, A L IR - Canto AL FIR - Carmona-Raphe, J IR - Carmona-Raphe J FIR - Carvalho-Neto, P B IR - Carvalho-Neto PB FIR - Casemiro, A F IR - Casemiro AF FIR - Cerione, M IR - Cerione M FIR - Cernea, C R IR - Cernea CR FIR - Cicco, R IR - Cicco R FIR - Chagas, M J IR - Chagas MJ FIR - Chedid, H IR - Chedid H FIR - Chiappini, P B O IR - Chiappini PB FIR - Correia, L A IR - Correia LA FIR - Costa, A IR - Costa A FIR - Costa, A C W IR - Costa AC FIR - Cunha, B R IR - Cunha BR FIR - Curioni, O A IR - Curioni OA FIR - Dias, T H G IR - Dias TH FIR - Durazzo, M IR - Durazzo M FIR - Ferraz, A R IR - Ferraz AR FIR - Figueiredo, R O IR - Figueiredo RO FIR - Fortes, C S IR - Fortes CS FIR - Franzi, S A IR - Franzi SA FIR - Frizzera, A P Z IR - Frizzera AP FIR - Gallo, J IR - Gallo J FIR - Gazito, D IR - Gazito D FIR - Guimaraes, P E M IR - Guimaraes PE FIR - Gutierres, A P IR - Gutierres AP FIR - Inamine, R IR - Inamine R FIR - Kaneto, C M IR - Kaneto CM FIR - Lehn, C N IR - Lehn CN FIR - Lopez, R V M IR - Lopez RV FIR - Macarenco, R IR - Macarenco R FIR - Magalhaes, R P IR - Magalhaes RP FIR - Martins, A E IR - Martins AE FIR - Meneses, C IR - Meneses C FIR - Mercante, A M C IR - Mercante AM FIR - Montenegro, F L M IR - Montenegro FL FIR - Pinheiro, D G IR - Pinheiro DG FIR - Polachini, G M IR - Polachini GM FIR - Porsani, A F IR - Porsani AF FIR - Rapoport, A IR - Rapoport A FIR - Rodini, C O IR - Rodini CO FIR - Rodrigues, A N IR - Rodrigues AN FIR - Rodrigues-Lisoni, F C IR - Rodrigues-Lisoni FC FIR - Rodrigues, R V IR - Rodrigues RV FIR - Rossi, L IR - Rossi L FIR - Santos, A R D IR - Santos AR FIR - Santos, M IR - Santos M FIR - Settani, F IR - Settani F FIR - Silva, F A M IR - Silva FA FIR - Silva, I T IR - Silva IT FIR - Silva-Filho, G B IR - Silva-Filho GB FIR - Smith, R B IR - Smith RB FIR - Souza, T B IR - Souza TB FIR - Stabenow, E IR - Stabenow E FIR - Takamori, J T IR - Takamori JT FIR - Tavares, M R IR - Tavares MR FIR - Turcano, R IR - Turcano R FIR - Valentim, P J IR - Valentim PJ FIR - Vidotto, A IR - Vidotto A FIR - Volpi, E M IR - Volpi EM FIR - Xavier, F C A IR - Xavier FC FIR - Yamagushi, F IR - Yamagushi F FIR - Cominato, M L IR - Cominato ML FIR - Correa, P M S IR - Correa PM FIR - Mendes, G S IR - Mendes GS FIR - Paiva, R IR - Paiva R FIR - Ramos, O IR - Ramos O FIR - Silva, C IR - Silva C FIR - Silva, M J IR - Silva MJ FIR - Tarla, M V C IR - Tarla MV EDAT- 2008/12/17 09:00 MHDA- 2009/02/04 09:00 CRDT- 2008/12/17 09:00 PHST- 2008/12/17 09:00 [entrez] PHST- 2008/12/17 09:00 [pubmed] PHST- 2009/02/04 09:00 [medline] AID - HIS3186 [pii] AID - 10.1111/j.1365-2559.2008.03186.x [doi] PST - ppublish SO - Histopathology. 2008 Dec;53(6):715-27. doi: 10.1111/j.1365-2559.2008.03186.x.