PMID- 19077123
OWN - NLM
STAT- MEDLINE
DCOM- 20090612
LR  - 20211020
IS  - 1460-9568 (Electronic)
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 29
IP  - 2
DP  - 2009 Jan
TI  - A centrifugal pathway to the mouse accessory olfactory bulb from the medial 
      amygdala conveys gender-specific volatile pheromonal signals.
PG  - 368-76
LID - 10.1111/j.1460-9568.2008.06564.x [doi]
AB  - We previously found that female mice exhibited Fos responses in the accessory 
      olfactory bulb (AOB) after exposure to volatile opposite-sex, but not same-sex, 
      urinary odours. This effect was eliminated by lesioning the main olfactory 
      epithelium, raising the possibility that the AOB receives information about 
      gender via centrifugal inputs originating in the main olfactory system instead of 
      from the vomeronasal organ. We asked which main olfactory forebrain targets send 
      axonal projections to the AOB, and whether these input neurons express Fos in 
      response to opposite-sex urinary volatiles. Female mice received bilateral 
      injections of the retrograde tracer cholera toxin B (CTB), into the AOB, and were 
      exposed to either same- or opposite-sex volatile urinary odours 1 week later. We 
      found CTB-labeled cell bodies in several forebrain sites including the bed 
      nucleus of the accessory olfactory tract, the rostral portion of the medial 
      amygdala (MeA) and the posteromedial cortical nucleus of the amygdala. A 
      significant increase in the percentage of CTB/Fos co-labeled cells was seen only 
      in the MeA of female subjects exposed to male but not to female urinary 
      volatiles. In Experiment 2, CTB-injected females were later exposed to volatile 
      odours from male mouse urine, food, or cat urine. Again, a significant increase 
      in the percentage of CTB/Fos co-labeled cells was seen in the MeA of females 
      exposed to male mouse urinary volatiles but not to food or predator odours. Main 
      olfactory-MeA-AOB signaling may motivate approach behaviour to opposite-sex 
      pheromonal signals that ensure successful reproduction.
FAU - Martel, Kristine L
AU  - Martel KL
AD  - Department of Biology, Boston University, Boston, MA 02215, USA.
FAU - Baum, Michael J
AU  - Baum MJ
LA  - eng
GR  - R01 HD044897/HD/NICHD NIH HHS/United States
GR  - R01 HD044897-06/HD/NICHD NIH HHS/United States
GR  - HD 044897/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20081211
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - 0 (Sex Attractants)
RN  - 9012-63-9 (Cholera Toxin)
SB  - IM
MH  - Amygdala/cytology/*physiology
MH  - Animals
MH  - Brain Mapping
MH  - Cholera Toxin
MH  - Efferent Pathways/cytology/physiology
MH  - Female
MH  - Male
MH  - Mice
MH  - Neurons/metabolism
MH  - Odorants
MH  - Olfactory Bulb/cytology/*physiology
MH  - Olfactory Pathways/cytology/*physiology
MH  - Proto-Oncogene Proteins c-fos/metabolism
MH  - Sex Attractants/*physiology
MH  - *Sex Characteristics
MH  - Sexual Behavior, Animal/physiology
MH  - Signal Transduction/physiology
MH  - Smell/*physiology
MH  - Staining and Labeling
PMC - PMC2754263
MID - NIHMS142124
EDAT- 2008/12/17 09:00
MHDA- 2009/06/13 09:00
PMCR- 2009/09/29
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/06/13 09:00 [medline]
PHST- 2009/09/29 00:00 [pmc-release]
AID - EJN6564 [pii]
AID - 10.1111/j.1460-9568.2008.06564.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2009 Jan;29(2):368-76. doi: 10.1111/j.1460-9568.2008.06564.x. 
      Epub 2008 Dec 11.