PMID- 19077159
OWN - NLM
STAT- MEDLINE
DCOM- 20090514
LR  - 20090203
IS  - 1365-2141 (Electronic)
IS  - 0007-1048 (Linking)
VI  - 144
IP  - 5
DP  - 2009 Mar
TI  - Interleukin 18 and interleukin 18 binding protein in patients with idiopathic 
      thrombocytopenic purpura.
PG  - 755-61
LID - 10.1111/j.1365-2141.2008.07520.x [doi]
AB  - To evaluate the balance of interleukin IL18 and its endogenous antagonist IL18 
      binding protein (IL18BP) in patients with idiopathic thrombocytopenic purpura 
      (ITP), plasma IL18, IL18BP, interferon gamma (IFNG) and IL4 levels, as well as 
      platelet counts were measured in patients with active ITP (n = 23), ITP in 
      remission (n = 21) and in healthy subjects (n = 24) by enzyme linked 
      immunosorbent assay (ELISA). Using real-time quantitative polymerase chain 
      reaction, the mRNA expression of IL18, IL18BP, IFNG, IL4, T-box (TBX21) and 
      GATA-binding protein 3(GATA3) were studied in all subjects. The results showed 
      that IL18 and IFNG protein and mRNA levels were significantly increased in 
      patients with active ITP than in control subjects, but that IL18BP were not 
      significantly elevated in ITP patients, which resulted in an elevated ratio of 
      IL18/IL18BP in patients with active disease. During remission stages, the levels 
      of these cytokines were comparable to those of healthy controls. The elevated 
      levels of IL18/IL18BP in plasma during active stages of disease suggest a 
      possible role in the pathogenesis and course of ITP.
FAU - Shan, Ning-Ning
AU  - Shan NN
AD  - Haematology Oncology Centre, Qilu Hospital, Shandong University, Jinan, China.
FAU - Zhu, Xiao-Juan
AU  - Zhu XJ
FAU - Peng, Jun
AU  - Peng J
FAU - Qin, Ping
AU  - Qin P
FAU - Zhuang, Xue-Wei
AU  - Zhuang XW
FAU - Wang, Hong-Chun
AU  - Wang HC
FAU - Hou, Ming
AU  - Hou M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20081205
PL  - England
TA  - Br J Haematol
JT  - British journal of haematology
JID - 0372544
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Interleukin-18)
RN  - 0 (RNA, Messenger)
RN  - 0 (interleukin-18 binding protein)
RN  - 207137-56-2 (Interleukin-4)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins/*blood/genetics
MH  - Interferon-gamma/blood/genetics
MH  - Interleukin-18/*blood/genetics
MH  - Interleukin-4/blood/genetics
MH  - Male
MH  - Middle Aged
MH  - Platelet Count
MH  - Purpura, Thrombocytopenic, Idiopathic/genetics/*immunology
MH  - RNA, Messenger/analysis
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Th1 Cells/immunology
MH  - Th2 Cells/immunology
MH  - Young Adult
EDAT- 2008/12/17 09:00
MHDA- 2009/05/15 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/05/15 09:00 [medline]
AID - BJH7520 [pii]
AID - 10.1111/j.1365-2141.2008.07520.x [doi]
PST - ppublish
SO  - Br J Haematol. 2009 Mar;144(5):755-61. doi: 10.1111/j.1365-2141.2008.07520.x. 
      Epub 2008 Dec 5.