PMID- 19077717
OWN - NLM
STAT- MEDLINE
DCOM- 20090320
LR  - 20211020
IS  - 1531-6963 (Electronic)
IS  - 1040-8711 (Print)
IS  - 1040-8711 (Linking)
VI  - 21
IP  - 1
DP  - 2009 Jan
TI  - Thromboembolic disease in vasculitis.
PG  - 41-6
LID - 10.1097/BOR.0b013e32831de4e7 [doi]
AB  - PURPOSE OF REVIEW: To give an overview of recent clinical findings of 
      thromboembolic disease in vasculitis and provide insight into possible 
      explanations of the association between thrombosis and inflammation. RECENT 
      FINDINGS: A high incidence of venous thrombotic events has recently been 
      described in four distinct cohorts of patients with antineutrophil cytoplasmic 
      antibody-associated vasculitis (AAV), especially during periods of active 
      disease. No factors other than the vasculitis itself have been identified that 
      explain this high occurrence of thrombosis. Several studies have shown an 
      increased rate of thrombosis in Behcet's disease, with a different clinical 
      presentation from that observed in AAV. Recent laboratory findings provide 
      exciting insights into a bidirectional feedback loop between coagulation and 
      inflammation that may be applicable to vasculitis. SUMMARY: Thrombosis is an 
      important clinical manifestation of some types of vasculitis. Better 
      understanding of the association of thrombosis with inflammation in vasculitis 
      might lead to development of clinically useful biomarkers and new approaches to 
      therapy. Additionally, study of the specific factors involved in thrombosis in 
      systemic vasculitis could help explain the role of inflammation in more common 
      settings of venous thrombotic events.
FAU - Tomasson, Gunnar
AU  - Tomasson G
AD  - The Vasculitis Center, Boston University School of Medicine and Boston Medical 
      Center, Boston, Massachusetts 02118, USA.
FAU - Monach, Paul A
AU  - Monach PA
FAU - Merkel, Peter A
AU  - Merkel PA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Rheumatol
JT  - Current opinion in rheumatology
JID - 9000851
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Autoantibodies/immunology
MH  - Behcet Syndrome/immunology
MH  - Biomarkers/analysis
MH  - Blood Coagulation Disorders/*immunology/*physiopathology/therapy
MH  - Diagnosis, Differential
MH  - Humans
MH  - Immunotherapy/trends
MH  - Neutrophils/immunology
MH  - Thromboembolism/*immunology/*physiopathology/therapy
MH  - Vasculitis/*complications/*immunology
PMC - PMC3204384
MID - NIHMS202755
EDAT- 2008/12/17 09:00
MHDA- 2009/03/21 09:00
PMCR- 2011/10/30
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/03/21 09:00 [medline]
PHST- 2011/10/30 00:00 [pmc-release]
AID - 00002281-200901000-00008 [pii]
AID - 10.1097/BOR.0b013e32831de4e7 [doi]
PST - ppublish
SO  - Curr Opin Rheumatol. 2009 Jan;21(1):41-6. doi: 10.1097/BOR.0b013e32831de4e7.