PMID- 19079211
OWN - NLM
STAT- MEDLINE
DCOM- 20090409
LR  - 20230203
IS  - 1935-3456 (Electronic)
IS  - 1933-0219 (Linking)
VI  - 1
IP  - 6
DP  - 2008 Nov
TI  - Division of labor between dendritic cell subsets of the lung.
PG  - 442-50
LID - 10.1038/mi.2008.39 [doi]
AB  - Dendritic cells (DCs) are a heterogenous population of antigen-presenting cells, 
      of which conventional DCs and plasmacytoid DCs are the main subsets. Like DC 
      subsets in the central lymphoid organs, DC subsets in the lungs exert specific 
      functions that can be associated with distinct expression of endocytic receptors, 
      cell-surface molecules, and anatomical location within the lung. In recent years, 
      DC populations are increasingly split up into a seemingly endless number of 
      defined sub-populations. We argue that this is not a "stamp-collecting" activity 
      but essential for a deeper understanding of the immune response to pathogens like 
      respiratory viruses or tolerance to harmless antigens. In homeostatic conditions, 
      a fine-tuned balance exists between the various functions of lung DC subsets, 
      which is necessary for maintaining immune homeostasis in the lung. However, 
      infectious or inflammatory conditions can profoundly alter the functions of 
      steady-state DC subsets and recruit inflammatory type DCs to the lung. This might 
      be important for clearing the inflicting pathogenic stimulus, but could at the 
      same time also be involved in causing immune pathology.
FAU - GeurtsvanKessel, C H
AU  - GeurtsvanKessel CH
AD  - Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, 
      The Netherlands.
FAU - Lambrecht, B N
AU  - Lambrecht BN
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20080917
PL  - United States
TA  - Mucosal Immunol
JT  - Mucosal immunology
JID - 101299742
RN  - 0 (Antigens)
SB  - IM
MH  - Animals
MH  - Antigens/immunology
MH  - Asthma/immunology
MH  - Dendritic Cells/cytology/*immunology/*metabolism
MH  - Humans
MH  - Lung/*cytology/*immunology
MH  - Respiratory Tract Infections/immunology/virology
RF  - 110
EDAT- 2008/12/17 09:00
MHDA- 2009/04/10 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/04/10 09:00 [medline]
AID - S1933-0219(22)01704-4 [pii]
AID - 10.1038/mi.2008.39 [doi]
PST - ppublish
SO  - Mucosal Immunol. 2008 Nov;1(6):442-50. doi: 10.1038/mi.2008.39. Epub 2008 Sep 17.