PMID- 19079212
OWN - NLM
STAT- MEDLINE
DCOM- 20090409
LR  - 20230203
IS  - 1935-3456 (Electronic)
IS  - 1933-0219 (Print)
IS  - 1933-0219 (Linking)
VI  - 1
IP  - 6
DP  - 2008 Nov
TI  - Dendritic cells and macrophages in the genitourinary tract.
PG  - 451-9
LID - 10.1038/mi.2008.57 [doi]
AB  - Dendritic cells (DCs) and macrophages are antigen-presenting cells (APCs) that 
      are important in innate immune defense as well as in the generation and 
      regulation of adaptive immunity against a wide array of pathogens. The 
      genitourinary (GU) tract, which serves an important reproductive function, is 
      constantly exposed to numerous agents of sexually transmitted infections (STIs). 
      To combat these STIs, several subsets of DCs and macrophages are strategically 
      localized within the GU tract. In the female genital mucosa, recruitment and 
      function of these APCs are uniquely governed by sex hormones. This review 
      summarizes the latest advances in our understanding of DCs and macrophages in the 
      GU tract with respect to their subsets, lineage, and function. In addition, we 
      discuss the divergent roles of these cells in immune defense against STIs as well 
      as in maternal tolerance to the fetus.
FAU - Iijima, N
AU  - Iijima N
AD  - Department of Immunobiology, Yale University School of Medicine, New Haven, 
      Connecticut, USA.
FAU - Thompson, J M
AU  - Thompson JM
FAU - Iwasaki, A
AU  - Iwasaki A
LA  - eng
GR  - T32 AI007019/AI/NIAID NIH HHS/United States
GR  - AI064705/AI/NIAID NIH HHS/United States
GR  - AI054359/AI/NIAID NIH HHS/United States
GR  - R01 AI054359-05/AI/NIAID NIH HHS/United States
GR  - R01 AI054359/AI/NIAID NIH HHS/United States
GR  - AI 062428/AI/NIAID NIH HHS/United States
GR  - R56 AI062428/AI/NIAID NIH HHS/United States
GR  - R01 AI062428/AI/NIAID NIH HHS/United States
GR  - R01 AI064705-04/AI/NIAID NIH HHS/United States
GR  - R01 AI064705/AI/NIAID NIH HHS/United States
GR  - R01 AI062428-05/AI/NIAID NIH HHS/United States
GR  - T32 AI07019/AI/NIAID NIH HHS/United States
GR  - R01 EB000487/EB/NIBIB NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080910
PL  - United States
TA  - Mucosal Immunol
JT  - Mucosal immunology
JID - 101299742
RN  - 0 (Gonadal Steroid Hormones)
SB  - IM
MH  - Animals
MH  - Dendritic Cells/cytology/*immunology/metabolism
MH  - Gonadal Steroid Hormones/metabolism
MH  - Humans
MH  - Immune Tolerance/immunology
MH  - Macrophages/cytology/*immunology/metabolism
MH  - Sexually Transmitted Diseases/immunology
MH  - Urogenital System/*immunology/metabolism
PMC - PMC2684461
MID - NIHMS89691
EDAT- 2008/12/17 09:00
MHDA- 2009/04/10 09:00
PMCR- 2009/05/19
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/04/10 09:00 [medline]
PHST- 2009/05/19 00:00 [pmc-release]
AID - S1933-0219(22)01705-6 [pii]
AID - 10.1038/mi.2008.57 [doi]
PST - ppublish
SO  - Mucosal Immunol. 2008 Nov;1(6):451-9. doi: 10.1038/mi.2008.57. Epub 2008 Sep 10.