PMID- 19079338
OWN - NLM
STAT- MEDLINE
DCOM- 20090310
LR  - 20211020
IS  - 1476-5594 (Electronic)
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 28
IP  - 7
DP  - 2009 Feb 19
TI  - Menin interacts with IQGAP1 to enhance intercellular adhesion of beta-cells.
PG  - 973-82
LID - 10.1038/onc.2008.435 [doi]
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a dominantly inherited tumor 
      syndrome that results from the mutation of the MEN1 gene that encodes protein 
      menin. Stable overexpression of MEN1 has been shown to partially suppress the 
      Ras-mediated morphological changes of fibroblast cells. Little is known about the 
      molecular mechanisms by which menin decreases the oncogenic effects on cell 
      morphology and other phenotypes. Here we showed that ectopic expression of menin 
      in pretumor beta-cells increases islet cell adhesion and reduces cell migration. 
      Our further studies revealed that menin interacts with the scaffold protein, IQ 
      motif containing GTPase activating protein 1 (IQGAP1), reduces GTP-Rac1 
      interaction with IQGAP1 but increases epithelial cadherin 
      (E-cadherin)/beta-catenin interaction with IQGAP1. Consistent with an essential 
      role for menin in regulating beta-cell adhesion in vivo, accumulations of 
      beta-catenin and E-cadherin are reduced at cell junctions in the islets from 
      Men1-excised mice. Together, these results define a novel menin-IQGAP1 pathway 
      that controls cell migration and cell-cell adhesion in endocrine cells.
FAU - Yan, J
AU  - Yan J
AD  - Department of Cancer Biology, Abramson Family Cancer Research Institute, 
      University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
FAU - Yang, Y
AU  - Yang Y
FAU - Zhang, H
AU  - Zhang H
FAU - King, C
AU  - King C
FAU - Kan, H-M
AU  - Kan HM
FAU - Cai, Y
AU  - Cai Y
FAU - Yuan, C-X
AU  - Yuan CX
FAU - Bloom, G S
AU  - Bloom GS
FAU - Hua, X
AU  - Hua X
LA  - eng
GR  - R01 NS051746-04/NS/NINDS NIH HHS/United States
GR  - R01-CA-100912/CA/NCI NIH HHS/United States
GR  - R01 CA113962/CA/NCI NIH HHS/United States
GR  - R01-NS-051746/NS/NINDS NIH HHS/United States
GR  - R01 CA113962-04/CA/NCI NIH HHS/United States
GR  - R01-CA-113962/CA/NCI NIH HHS/United States
GR  - R01 NS051746-03/NS/NINDS NIH HHS/United States
GR  - R01 CA100912/CA/NCI NIH HHS/United States
GR  - R01 NS051746/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20081215
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Actins)
RN  - 0 (Cadherins)
RN  - 0 (IQ motif containing GTPase activating protein 1)
RN  - 0 (MEN1 protein, human)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (RNA, Small Interfering)
RN  - 0 (beta Catenin)
RN  - 0 (ras GTPase-Activating Proteins)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 3.6.5.2 (rac1 GTP-Binding Protein)
SB  - IM
MH  - Actins/metabolism
MH  - Animals
MH  - Cadherins/metabolism
MH  - Cell Adhesion/*physiology
MH  - Cell Membrane/metabolism
MH  - Cell Movement/physiology
MH  - Cells, Cultured
MH  - Genes, Tumor Suppressor
MH  - Guanosine Triphosphate/metabolism
MH  - Humans
MH  - Insulin-Secreting Cells/*metabolism
MH  - Intercellular Junctions/*metabolism
MH  - Mice
MH  - Microscopy, Fluorescence
MH  - Proto-Oncogene Proteins/genetics/*metabolism
MH  - RNA, Small Interfering/pharmacology
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
MH  - beta Catenin/metabolism
MH  - rac1 GTP-Binding Protein/metabolism
MH  - ras GTPase-Activating Proteins/antagonists & inhibitors/genetics/*metabolism
PMC - PMC2645484
MID - NIHMS77188
EDAT- 2008/12/17 09:00
MHDA- 2009/03/11 09:00
PMCR- 2009/08/19
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/03/11 09:00 [medline]
PHST- 2009/08/19 00:00 [pmc-release]
AID - onc2008435 [pii]
AID - 10.1038/onc.2008.435 [doi]
PST - ppublish
SO  - Oncogene. 2009 Feb 19;28(7):973-82. doi: 10.1038/onc.2008.435. Epub 2008 Dec 15.