PMID- 19080076
OWN - NLM
STAT- MEDLINE
DCOM- 20090611
LR  - 20081216
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 88
IP  - 42
DP  - 2008 Nov 18
TI  - [Relationship between vascular endothelial growth factor C expression level and 
      lymph node metastasis in non small cell lung cancer].
PG  - 2982-5
AB  - OBJECTIVE: To investigate the relationship between vascular endothelial growth 
      factor C (VEGF-C) expression level and lymph node metastasis in non small cell 
      lung cancer (NSCLC). METHODS: Fifty-two NSCLC patients, 38 males and 14 females, 
      aged (59+/-11) (29-77), were divided into 2 groups based on the pathological 
      examination: lymph node metastasis positive group (n=25) and lymph node 
      metastasis negative group (n=27). RT-PCR and immunohistochemistry were used to 
      detect the mRNA and protein expression of VEGF-C in the tumor tissues and lymph 
      nodes resected during operation. RESULTS: The VEGF-C mRNA expression level in the 
      lung tumor tissue of the lymph node metastasis positive group was 0.273+/-0.179, 
      significantly higher than that in the lymph node metastasis negative group 
      (0.089+/-0.087, P<0.01). The VEGF-C mRNA expression level in the positive lymph 
      node of the lymph node metastasis positive group was 0.207+/-0.174, significantly 
      higher than that in the lymph node metastasis negative group (0.114+/-0.107, 
      P<0.01), but not significantly different from that in the negative lymph nodes of 
      the same group(0.196+/-0.186, P>0.05). The VEGF-C protein positive rate of the 
      lung cancer tissues of the lymph node metastasis positive group was 93.3% 
      (14/15), significantly higher than that of the lymph node metastasis negative 
      group (6.7%, 1/15, P<0.01). The VEGF-C protein positive rate of the metastasis 
      positive lymph noses was 80.4% (37/46), and all 52 metastasis negative lymph 
      nodes were VEGF-C protein negative. CONCLUSION: VEGF-C mRNA and protein 
      expression levels predict lymph node metastasis and can be useful predictors of 
      lymph node metastasis in NSCLC.
FAU - Li, Jie
AU  - Li J
AD  - Combination Department, Beijing Chest Hospital, Beijing 101149, China.
FAU - Li, Bao-lan
AU  - Li BL
FAU - Zhang, Hai-qing
AU  - Zhang HQ
FAU - Xu, Shao-fa
AU  - Xu SF
FAU - Liu, Zhi-dong
AU  - Liu ZD
FAU - Yue, Wen-tao
AU  - Yue WT
FAU - Han, Yi
AU  - Han Y
LA  - chi
PT  - English Abstract
PT  - Journal Article
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
RN  - 0 (RNA, Messenger)
RN  - 0 (Vascular Endothelial Growth Factor C)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carcinoma, Non-Small-Cell Lung/*metabolism/pathology
MH  - Female
MH  - Humans
MH  - Lymph Nodes/*pathology
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - RNA, Messenger/metabolism
MH  - Vascular Endothelial Growth Factor C/*metabolism
EDAT- 2008/12/17 09:00
MHDA- 2009/06/12 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/06/12 09:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2008 Nov 18;88(42):2982-5.