PMID- 19080645
OWN - NLM
STAT- MEDLINE
DCOM- 20090528
LR  - 20081216
IS  - 0376-2491 (Print)
IS  - 0376-2491 (Linking)
VI  - 88
IP  - 36
DP  - 2008 Sep 23
TI  - [Genetic characteristics of familial type 2 diabetes pedigrees: a preliminary 
      analysis of 4468 persons from 715 pedigrees].
PG  - 2541-3
AB  - OBJECTIVE: To analyze the inheritance character of type 2 diabetes mellitus 
      (T2DM) pedigrees. METHODS: 4468 persons from 715 T2DM pedigrees (including the 
      spouses) undergo peripheral blood sample collection to examine blood sugar and 
      physical examination. Questionnaire survey was conducted to explore the family 
      history. Type 1 DM and maturity-onset DM of young people were to be ruled out. 
      Pedigree chart were made. RESULTS: The prevalence rates of T2DM and impaired 
      glucose regulation (IGR) was 47.62%, including 218 T2DM and 422 IGR newly 
      discovered. The prevalence rates of T2DM and IGR were 38.33% and 14.25% in the 
      siblings, and 56.81% and 12.58% in the parents, all significantly higher than 
      those in the second-degree relatives (9.55% and 6.10%) and spouses (10.57% and 
      9.55% respectively, all P < 0.01). The prevalence and newly discovered rates of 
      IGR in the offspring were 12.46% and 11.73% respectively, both significantly 
      higher than those in the spouses (9.55% and 9.55% respectively, all P < 0.01). 
      CONCLUSION: There is significant familial aggregation in T2DM. The first-degree 
      relatives of T2DM patients are high risk populations, so long term monitoring and 
      early screening should be performed.
FAU - Ma, Xiao-jing
AU  - Ma XJ
AD  - Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of 
      Endocrinology & Metabolism of Shanghai Jiaotong University Affiliated Sixth 
      People's Hospital, Shanghai 200233, China.
FAU - Jia, Wei-ping
AU  - Jia WP
FAU - Hu, Cheng
AU  - Hu C
FAU - Zhou, Jian
AU  - Zhou J
FAU - Lu, Hui-juan
AU  - Lu HJ
FAU - Zhang, Rong
AU  - Zhang R
FAU - Wang, Cong-rong
AU  - Wang CR
FAU - Wu, Song-hua
AU  - Wu SH
FAU - Xiang, Kun-san
AU  - Xiang KS
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Yi Xue Za Zhi
JT  - Zhonghua yi xue za zhi
JID - 7511141
SB  - IM
MH  - Adult
MH  - Aged
MH  - China/epidemiology
MH  - Diabetes Mellitus, Type 2/epidemiology/*genetics
MH  - Family
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Pedigree
MH  - Prevalence
EDAT- 2008/12/17 09:00
MHDA- 2009/05/29 09:00
CRDT- 2008/12/17 09:00
PHST- 2008/12/17 09:00 [entrez]
PHST- 2008/12/17 09:00 [pubmed]
PHST- 2009/05/29 09:00 [medline]
PST - ppublish
SO  - Zhonghua Yi Xue Za Zhi. 2008 Sep 23;88(36):2541-3.